Widrich W C, Singer R J, Robbins A H
Radiology. 1977 Jul;124(1):37-41. doi: 10.1148/124.1.37.
Intra-arterial lidocaine has been utilized to decrease pain by administration prior to contrast material injections during aortofemoral arteriography in over 600 patients. Because this observation was uncontrolled, a double-blind study was performed in 15 patients comparing the effectiveness of intra-arterial lidocaine and saline in the control of pain from contrast material injections (methylglucamine iothalamate) in pelvic and peripheral arteriography. Two per cent lidocaine was compared with 1% lidocaine in the same manner in an additional 10 patients. Peripheral vein blood samples were obtained in 4 patients to measure the plasma concentration of lidocaine. Intra-arterial lidocaine is safe and effective in reducing pain from intra-arterial contrast agent injections.
在超过600例患者的主-股动脉造影中，动脉内注射利多卡因已被用于在注射造影剂之前给药以减轻疼痛。由于该观察无对照，因此对15例患者进行了一项双盲研究，比较动脉内注射利多卡因和生理盐水在盆腔和外周血管造影中控制造影剂（碘他拉葡胺）注射所致疼痛的效果。另外10例患者以同样方式比较了2%利多卡因和1%利多卡因。对4例患者采集外周静脉血样以测量利多卡因的血浆浓度。动脉内注射利多卡因在减轻动脉内注射造影剂所致疼痛方面安全有效。
