Ancu Oana, Mackenzie Richard W A, Patterson Michael, Dsilva Evone, Yakubov Gleb E, Haynes Michael, Kolida Sofia, Stephenson Christopher G, Costabile Adele
School of Life and Health Sciences, University of Roehampton, London, SW15 4 JD, UK.
Institute of Cardio-Metabolic Medicine, Coventry University, University Hospital Coventry & Warwick NHS Trust, Coventry, CV15 FB, UK.
Eur J Nutr. 2025 Jun 9;64(5):216. doi: 10.1007/s00394-025-03732-8.
To investigate the effects of a chromium-enriched glucomannan-fructooligosaccharide complex (SB) on glycaemic and insulin responses, satiation, and hunger biomarkers in healthy adults.
Using a double-blind, placebo-controlled, randomised crossover design, we assessed the acute impact of a single 3 g SB dose in 16 healthy adults (BMI 18.5-24.9 kg/m) during a modified oral glucose tolerance test. On separate days, participants consumed 50 g dextrose or 50 g dextrose with 3 g SB (SBD). Blood glucose and insulin were analysed over 2.5 h. Hunger, fullness, and desire to eat were assessed via visual analogue scales. Additionally, the impact of SB on gastric viscosity was assessed in vitro.
SBD intake significantly reduced the insulin concentration compared to dextrose alone at 45, 75, and 90 min post-intake. Additionally, SBD resulted in significantly greater fullness and a lower desire to eat at 75 min when compared to dextrose (p < 0.05). Although hunger increased over time for both interventions, SBD led to lower hunger, desire to eat, and food desire scores compared to dextrose at 150 min (p < 0.05). The viscosity of SB, even when combined with dextrose, was significantly higher compared to dextrose alone.
These novel findings suggest that SB can modulate insulin response and influence appetite regulation, highlighting its potential use in weight management strategies.
研究富含铬的葡甘露聚糖-低聚果糖复合物（SB）对健康成年人血糖和胰岛素反应、饱腹感及饥饿生物标志物的影响。
采用双盲、安慰剂对照、随机交叉设计，在改良口服葡萄糖耐量试验中，我们评估了16名健康成年人（BMI 18.5 - 24.9 kg/m）单次服用3 g SB剂量的急性影响。在不同日期，参与者分别食用50 g葡萄糖或50 g葡萄糖加3 g SB（SBD）。在2.5小时内分析血糖和胰岛素水平。通过视觉模拟量表评估饥饿感、饱腹感和进食欲望。此外，在体外评估SB对胃黏度的影响。
与单独服用葡萄糖相比，摄入SBD后45、75和90分钟时胰岛素浓度显著降低。此外，与葡萄糖相比，SBD在75分钟时导致显著更高的饱腹感和更低的进食欲望（p < 0.05）。尽管两种干预措施下饥饿感均随时间增加，但在150分钟时，与葡萄糖相比，SBD导致更低的饥饿感、进食欲望和食物渴望得分（p < 0.05）。即使与葡萄糖混合，SB的黏度也显著高于单独的葡萄糖。
这些新发现表明，SB可调节胰岛素反应并影响食欲调节，凸显了其在体重管理策略中的潜在应用价值。
