Srivastava P K, Tyagi S R, Misra U K
Toxicology. 1985 Aug;36(2-3):171-81. doi: 10.1016/0300-483x(85)90052-6.
The effect of intratracheal administration of fly ash, benzene extracted fly ash residue and benzene extract of fly ash has been studied on the activity of pulmonary mixed function oxidase. Fly ash, its benzene extract and benzene extracted residue significantly increased the levels of cytochrome P-450, cytochrome b5 and the activities of NADPH-cytochrome c reductase, NADH cytochrome b5 reductase, aminopyrine N-demethylase and glutathione S-transferase in a dose dependent manner. Phenobarbital or 3-methylcholanthrene treatment along with administration of fly ash, its benzene extracted residue and benzene extract of fly ash showed a synergistic effect on the activity of mixed function oxidase. The observed effects were due to chemical causes, i.e. organic and inorganic fractions of fly ash and not, due to its particulate nature. This was shown by the administration of glass beads which caused no alteration in the activity of pulmonary mixed function oxidase.
已研究了气管内给予粉煤灰、苯萃取粉煤灰残渣和粉煤灰苯提取物对肺混合功能氧化酶活性的影响。粉煤灰及其苯提取物和苯萃取残渣以剂量依赖方式显著提高了细胞色素P - 450、细胞色素b5的水平以及NADPH - 细胞色素c还原酶、NADH细胞色素b5还原酶、氨基比林N - 脱甲基酶和谷胱甘肽S - 转移酶的活性。苯巴比妥或3 - 甲基胆蒽处理与粉煤灰、其苯萃取残渣和粉煤灰苯提取物的给予一起，对混合功能氧化酶的活性显示出协同作用。观察到的影响是由于化学原因，即粉煤灰的有机和无机成分，而不是由于其颗粒性质。给予玻璃珠未引起肺混合功能氧化酶活性改变，证明了这一点。
