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同伴通过应急管理研究扩大减少兴奋剂危害参与度的研究:一篇方案论文。

The peers expanding engagement in stimulant harm reduction with contingency management study: a protocol paper.

作者信息

Cooke Alexis, Stack Erin, Peng Linda, Cook Ryan, Hartzler Bryan, Leichtling Gillian, Hildebran Christi, Leahy Judith M, Payne Kelsey Smith, Kunkel Lynn E, Hoffman Kim, Korthuis P Todd

机构信息

Comagine Health, 650 NE Holladay Street, Portland, OR, 97232, USA.

Department of Medicine, Division of General Internal Medicine, Section of Addiction Medicine, Oregon Health & Science University, Portland, OR, USA.

出版信息

Addict Sci Clin Pract. 2025 Jun 10;20(1):48. doi: 10.1186/s13722-025-00577-8.

Abstract

BACKGROUND

Contingency management (CM) that is delivered by peer recovery support specialists and incentivizes harm reduction goals among people not seeking treatment for stimulant use has not been tested. The Peers Expanding Engagement in Stimulant Harm Reduction with Contingency Management (PEER-CM) study compares the effectiveness of two peer-facilitated CM interventions: (1) an experimental approach incentivizing achievement of client-identified harm reduction goals and (2) an enhanced standard of care approach incentivizing peer visit attendance.

METHODS

Applying a hybrid type 1 effectiveness-implementation framework and stepped-wedge design across 14 community-based peer services sites across Oregon, the PEER-CM study trains peers to conduct CM. All sites implement the standard CM approach of incentivizing peer visit attendance. Every 2 months, two sites are randomly assigned to initiate the experimental CM condition of incentives for achieving client-directed harm reduction activities. Peers monitor progress and manage incentives. In the experimental approach, peers facilitate client progress on goal-related activities (selected from a standardized list of goals) to support the primary study outcome of reducing opioid overdoses and stimulant overamping. The intended study enrollment is approximately 80 clients per site (N = 1,120). Peer specialists participate in skills-focused coaching-to-criterion coaching process to document proficient CM delivery skills. This includes a series of group coaching sessions and an individual assessment with a standardized patient, observed and rated according to core dimensions of the Contingency Management Competence Scale.

RESULTS

The primary study outcome is time until peer-reported fatal or first participant-reported non-fatal overdose or overamp (acute stimulant toxicity). Secondary outcomes include achievement of client-identified harm reduction goals and engagement in substance use disorder treatment. We will also demonstrate the feasibility of our coaching-to-criterion process by documenting peer proficiency in CM skills. Qualitative interviews with peers and their clients will explore the optimal context and implementation strategies for peer-facilitated CM.

CONCLUSION

PEER-CM is among the first trials to test the effectiveness of peer-facilitated CM for achieving harm reduction goals and reducing overdose in non-treatment-seeking people who use stimulants. The findings will generate evidence for peer-facilitated delivery of CM and application of CM to client-identified harm reduction goals.

TRIAL REGISTRATION

This study is registered at ClinicalTrials.gov (NCT05700994).

摘要

背景

由同伴康复支持专家提供的应急管理(CM),并激励未寻求兴奋剂使用治疗的人群实现减少伤害目标,尚未经过测试。同伴扩大参与兴奋剂减少伤害应急管理(PEER-CM)研究比较了两种同伴主导的CM干预措施的有效性:(1)一种实验方法,激励实现客户确定的减少伤害目标;(2)一种强化的标准护理方法,激励同伴就诊出勤率。

方法

PEER-CM研究在俄勒冈州的14个社区同伴服务站点应用混合1型有效性-实施框架和阶梯楔形设计,培训同伴进行CM。所有站点都实施激励同伴就诊出勤率的标准CM方法。每2个月,随机分配两个站点启动针对实现客户导向的减少伤害活动的实验性CM条件。同伴监测进展并管理激励措施。在实验方法中,同伴促进客户在与目标相关的活动(从标准化目标列表中选择)上取得进展,以支持减少阿片类药物过量和兴奋剂过度使用这一主要研究结果。预期每个站点的研究入组人数约为80名客户(N = 1120)。同伴专家参与以技能为重点的达标指导过程,以记录熟练的CM实施技能。这包括一系列小组指导课程和对一名标准化患者的个人评估,根据应急管理能力量表的核心维度进行观察和评分。

结果

主要研究结果是直至同伴报告的致命或首次参与者报告的非致命过量用药或过度使用(急性兴奋剂毒性)的时间。次要结果包括实现客户确定的减少伤害目标以及参与物质使用障碍治疗。我们还将通过记录同伴在CM技能方面的熟练程度来证明我们的达标指导过程的可行性。对同伴及其客户的定性访谈将探索同伴主导的CM的最佳背景和实施策略。

结论

PEER-CM是首批测试同伴主导的CM对未寻求治疗的兴奋剂使用者实现减少伤害目标和减少过量用药有效性的试验之一。研究结果将为同伴主导的CM实施以及CM应用于客户确定的减少伤害目标提供证据。

试验注册

本研究已在ClinicalTrials.gov注册(NCT05700994)。

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J Subst Abuse Treat. 2022 Feb;133:108556. doi: 10.1016/j.jsat.2021.108556. Epub 2021 Jun 24.

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