Neglected tropical diseases (NTD), a broad set of infectious diseases prevalent in tropical and subtropical environments, are widely known to affect individuals with limited resources in underserved communities. Nigeria is one of the countries with the highest cases of NTD, with an estimated 100 million people in the country at risk for at least one NTD. In Nigeria, the NTD master plan recognizes behavioural change communication as an important part of its strategy for reducing the burden of NTDs. Behavioural change communication has been proven to be significant in preventing and reducing infection, spread and re-infection of diseases. However, poor communication strategies, lack of funds and human resources and lack of training on how to deliver behavioural change interventions are major challenges. Enhancing communication strategies will significantly help increase attention towards NTD prevention methods and acceptance of treatment interventions. It is also important to ensure that healthcare professionals are provided with adequate skills in the delivery of behavioural change interventions in the communities. This article reviews the activities to enhance communication strategies in the context settings of Nigeria.