Voß Johannes, Barisch Julian, Thieme René, Gockel Ines, Tegtbur Uwe, Leps Christian, Busse Martin, Falz Roberto
Institute of Sports Medicine and Prevention, Leipzig University, Leipzig, Germany.
Department of Visceral, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.
Support Care Cancer. 2025 Jun 11;33(7):566. doi: 10.1007/s00520-025-09608-1.
Cancer patients who have undergone curative treatment may retain chronic, low-grade inflammation, a condition known to promote carcinogenesis, and, thus, cancer recurrence. We aimed to investigate whether home-based online exercise training can mitigate chronic, low-grade inflammation of cancer patients after curative oncologic surgery.
We analyzed data sets from 145 patients with breast, prostate, or colorectal cancer after curative surgery in the randomized controlled multicenter CRBP-TS trial. The intervention group was instructed to exercise at least twice weekly via video presentations for 6 months. The control group received no video presentations. We analyzed the modified Glasgow prognostic score (mGPS) and plasma levels of interleukin (IL)-1 beta, IL-2, IL-6, IL-10, IL-12p70, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) at baseline, after 3 months, and after 6 months. Baseline values were compared to normative values of healthy populations. Mixed-effect models were applied for statistical analysis of intervention effects.
We detected baseline elevations of IL-1 beta, IL-2, IL-6, IL-10, IL-12p70, TNF-alpha, and IFN-gamma compared to normative values of healthy individuals. All patients in each group except for one had an mGPS of 0 at baseline. None of the cytokines revealed any significant interaction effects. After 6 months, all patients had an mGPS of 0.
Cancer patients may exhibit low-grade chronic inflammation after surgery. In this study, home-based online exercise training did not affect low-grade chronic inflammation. Future studies should further investigate the efficacy of home-based online exercise training considering adjunctive therapies, other exercise modalities, and cancer types.
DRKS-ID: DRKS00020499; Registered 17 March 2020. https://drks.de/search/en/trial/DRKS00020499.
接受根治性治疗的癌症患者可能会持续存在慢性低度炎症，这种情况已知会促进癌症发生，进而导致癌症复发。我们旨在研究居家在线运动训练是否能减轻癌症患者在根治性肿瘤切除术后的慢性低度炎症。
我们分析了随机对照多中心CRBP - TS试验中145例乳腺癌、前列腺癌或结直肠癌根治术后患者的数据集。干预组被要求通过视频演示每周至少锻炼两次，持续6个月。对照组未接受视频演示。我们在基线、3个月后和6个月后分析了改良格拉斯哥预后评分（mGPS）以及白细胞介素（IL）-1β、IL - 2、IL - 6、IL - 10、IL - 12p70、肿瘤坏死因子-α（TNF - α）和干扰素-γ（IFN - γ）的血浆水平。将基线值与健康人群的标准值进行比较。采用混合效应模型对干预效果进行统计分析。
与健康个体的标准值相比，我们检测到基线时IL - 1β、IL - 2、IL - 6、IL - 10、IL - 12p70、TNF - α和IFN - γ升高。除1例患者外，每组所有患者在基线时的mGPS均为0。细胞因子均未显示出任何显著的交互作用。6个月后，所有患者的mGPS均为0。
癌症患者术后可能表现出低度慢性炎症。在本研究中，居家在线运动训练并未影响低度慢性炎症。未来的研究应进一步考虑辅助治疗、其他运动方式和癌症类型，来研究居家在线运动训练的疗效。
DRKS编号：DRKS00020499；于2020年3月17日注册。https://drks.de/search/en/trial/DRKS00020499 。
