Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Department of Orthopedics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Front Endocrinol (Lausanne). 2023 Feb 3;14:1111277. doi: 10.3389/fendo.2023.1111277. eCollection 2023.
The relationship between the C-reactive protein (CRP) and prognosis in prostate cancer (PCa) has been widely discussed over the past few years but remains controversial.
In our meta-analysis, we searched 16 reliable studies in the PubMed, Embase, and Cochrane Library databases. Otherwise, we have successfully registered on the INPLASY. We also performed random- and fixed-effects models to evaluate the hazard ratio (HR) and 95% confidence interval (CI), respectively.
The result of our meta-analysis shows that elevated CRP levels were related to worse overall survival (OS) (HR = 1.752, 95% CI = 1.304-2.355, = 0.000), cancer-specific survival (CSS) (HR = 1.663, 95% CI = 1.064-2.6, = 0.026), and progression-free survival (PFS) (HR = 1.663, 95% CI = 1.064-2.6, = 0.026) of PCa patients. There was significant heterogeneity, so we performed a subgroup analysis according to the staging of the disease and found the same result. Furthermore, the heterogeneity was also reduced, and no statistical significance.
Our study shows that the level of CRP could reflect the prognosis of prostate cancer patients. We find that PCa patients with high levels of CRP often have worse OS, CSS, and PFS, although the stages of the patients' disease are different. More studies are needed to verify this idea.
过去几年，C 反应蛋白（CRP）与前列腺癌（PCa）预后之间的关系备受关注，但仍存在争议。
在我们的荟萃分析中，我们在 PubMed、Embase 和 Cochrane Library 数据库中搜索了 16 项可靠的研究。此外，我们还成功在 INPLASY 上进行了注册。我们还分别使用随机效应和固定效应模型来评估风险比（HR）和 95%置信区间（CI）。
荟萃分析的结果表明，CRP 水平升高与更差的总生存（OS）（HR=1.752，95%CI=1.304-2.355， = 0.000）、癌症特异性生存（CSS）（HR=1.663，95%CI=1.064-2.6， = 0.026）和无进展生存（PFS）（HR=1.663，95%CI=1.064-2.6， = 0.026）相关。存在显著的异质性，因此我们根据疾病的分期进行了亚组分析，得出了相同的结果。此外，异质性也有所降低，且无统计学意义。
我们的研究表明，CRP 水平可以反映前列腺癌患者的预后。我们发现，CRP 水平较高的 PCa 患者的 OS、CSS 和 PFS 往往更差，尽管患者的疾病分期不同。需要更多的研究来验证这一观点。
