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二芳基庚烷类化合物的合成新进展。

Recent Advances in the Synthesis of Diarylheptanoids.

机构信息

Kasireddy Sudarshan, Suresh Yarlagadda, Sagnik Sengupta, Department of Chemistry, Institute for Drug Discovery, Purdue University, West Lafayette, IN-47907, USA.

出版信息

Chem Asian J. 2024 Aug 1;19(15):e202400380. doi: 10.1002/asia.202400380. Epub 2024 Jun 23.

Abstract

In the quest for synthesizing biologically important natural products, medicinal chemists embark on an endless journey. This review focuses on the reports published towards the syntheses of diarylheptanoids, classifying them into linear, tetrahydropyran, diarylether, and biphenyl categories. The synthesis methods for each class from 2013 to 2023 are discussed, providing a comprehensive overview of the advancements in the field. Representative natural product examples are highlighted for each category. The review emphasizes the importance of diarylheptanoids in the realms of chemistry and medicine, showcasing their potential as valuable compounds for medicinal and synthetic chemists.

摘要

在合成具有生物重要性的天然产物的过程中,药物化学家们踏上了一条永无止境的探索之路。本综述重点关注了 2013 年至 2023 年间报道的二芳基庚烷类化合物的合成研究,将其分为直链型、四氢吡喃型、二芳基醚型和联苯型。本文对每种类别化合物的合成方法进行了讨论,全面概述了该领域的最新进展。每个类别都有代表性的天然产物实例进行了强调。本综述强调了二芳基庚烷类化合物在化学和医学领域的重要性,展示了它们作为有价值的化合物,对药物化学家和合成化学家具有潜在的吸引力。

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