Platzbecker Anna Lena, Gronewold Janine, Schramm Sara, Moebus Susanne, Stang Andreas, Schmidt Börge, Weimar Christian, Jokisch Martha
Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS) University Hospital of Essen University of Duisburg-Essen Essen Germany.
Fliedner University of Applied Science Düsseldorf Düsseldorf Germany.
Alzheimers Dement (Amst). 2025 Jun 11;17(2):e70130. doi: 10.1002/dad2.70130. eCollection 2025 Apr-Jun.
As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non-amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex- and age-specific effects of T2DM on incident MCI after five years in a population-based sample.
A total of 145 participants with T2DM and 1322 without T2DM were included. MCI was defined using established criteria excluding subjective cognitive decline. Adjusted relative risks (aRRs) were calculated considering age, education, body mass index, smoking, and alcohol intake, and stratified by sex and age (middle-aged: 50-65 years; old-aged: 66-80 years).
MCI occurred in 39.3% ( = 57) of participants with T2DM versus 27.5% ( = 363) without (aRR: 1.29, 95% confidence interval [CI]: 0.97-1.73). Middle-aged men showed an association with naMCI (aRR: 2.35, 95% CI: 1.26-4.39) and middle-aged women with aMCI (aRR: 2.05, 95% CI: 0.58-7.21).
T2DM increases MCI risk, particularly in middle-aged individuals with poorly controlled T2DM, emphasizing the need for prevention strategies.
Longitudinal results from the population-based Heinz Nixdorf Recall study in Germany.Incident mild cognitie impairment (MCI) was more common in type 2 diabetes mellitus (T2DM; 39% vs 28%).T2DM affects incident MCI and subtypes in middle-aged, not old-aged; stronger in men with poorly controlled T2DM.Importance of enhancing age- and sex-specific prevention at the population level.
由于关于2型糖尿病（T2DM）与轻度认知障碍（MCI）（包括遗忘型（aMCI）和非遗忘型（naMCI）亚型）之间关联的研究因性别和年龄而异，我们在一个基于人群的样本中调查了T2DM在五年后对新发MCI的性别和年龄特异性影响。
共纳入145名T2DM患者和1322名非T2DM患者。MCI采用既定标准定义，排除主观认知下降。在考虑年龄、教育程度、体重指数、吸烟和饮酒情况的基础上计算调整后的相对风险（aRRs），并按性别和年龄分层（中年：50 - 65岁；老年：66 - 80岁）。
T2DM患者中39.3%（n = 57）发生MCI，而非T2DM患者中为27.5%（n = 363）（aRR：1.29，95%置信区间[CI]：0.97 - 1.73）。中年男性与naMCI相关（aRR：2.35，95% CI：1.26 - 4.39），中年女性与aMCI相关（aRR：2.05，95% CI：0.58 - 7.21）。
T2DM增加MCI风险，尤其是在T2DM控制不佳的中年个体中，这强调了预防策略的必要性。
德国基于人群的海因茨·尼克斯多夫召回研究的纵向结果。新发轻度认知障碍（MCI）在2型糖尿病（T2DM）中更常见（39%对28%）。T2DM影响中年而非老年的新发MCI及其亚型；在T2DM控制不佳的男性中影响更强。在人群层面加强年龄和性别特异性预防的重要性。
