Garona J, Berard A, Tatard C, Kwasiborski A, Gauthier P, Ag Atteynine S, Hourdel V, Eusebe A, Diagne C, Caro V, Brouat C, Charbonnel N, Sauvage V, Granjon L, Castel G
CBGP, IRD, INRAE, CIRAD, Institut Agro, Univ Montpellier, Montpellier, France.
Institut Pasteur, Université Paris Cité, Environment and Infectious Risks Unit, Laboratory for Urgent Response to Biological Threats (CIBU), Paris, France.
One Health. 2025 May 23;20:101085. doi: 10.1016/j.onehlt.2025.101085. eCollection 2025 Jun.
(SEOV) and pathogenic leptospires, two zoonotic agents causing similar symptoms in humans, were investigated in rat populations across several neighborhoods in Bamako, Mali. SEOV seroprevalence in brown rats () reached 14.8 %, while no infection was detected in black rats (. Pathogenic leptospires were found in 8.7 % of brown rats, with significant inter-neighborhood variations, while only one black rat tested positive. Viral genetic analyses suggested that SEOV strains circulating in Bamako may result from a reassortment between two SEOV lineages. These findings highlight the widespread distribution of SEOV and the localized presence of pathogenic leptospires in Bamako, emphasizing the role of brown rats as reservoirs. These results can guide municipal authorities in implementing rodent control and prevention strategies to mitigate associated public health risks in Bamako.
在马里巴马科的几个街区的大鼠种群中，对两种在人类中引起相似症状的人畜共患病原体——首尔病毒（SEOV）和致病性钩端螺旋体进行了调查。褐家鼠中SEOV血清阳性率达到14.8%，而黑家鼠中未检测到感染。在8.7%的褐家鼠中发现了致病性钩端螺旋体，街区间存在显著差异，而只有一只黑家鼠检测呈阳性。病毒基因分析表明，在巴马科传播的SEOV毒株可能是两个SEOV谱系之间重组的结果。这些发现突出了SEOV在巴马科的广泛分布以及致病性钩端螺旋体的局部存在，强调了褐家鼠作为宿主的作用。这些结果可为市政当局实施啮齿动物控制和预防策略提供指导，以减轻巴马科相关的公共卫生风险。
