Zhou Xiangning, Yu Jingjing, Sun Tianwei, Wang Ying, Yao Zhenyu, Gao Ling
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Shandong Key Laboratory of Endocrine Metabolism and Aging, Jinan, China.
Toxicol Ind Health. 2025 Jul;41(7):386-397. doi: 10.1177/07482337251349366. Epub 2025 Jun 12.
Ferroptosis, a form of programmed iron-dependent cell death, is associated with various liver pathologies. Recent studies have increasingly highlighted the crucial role of ferroptosis in liver function. This study aimed to explore the development of ferroptosis in liver diseases through bibliometric analysis. We retrieved the data from the Web of Science (WOS) Core Collection, then imported selected articles into VOSviewer, CiteSpace, and Microsoft Excel for knowledge mapping analysis. A total of 1,236 articles were included in this study, showing a steady increase in publications on ferroptosis in the liver over the past 11 years, with a significant surge in recent years. China emerged as a dominant contributor, accounting for 86% of global publications. Key institutions included Zhejiang University and Sun Yat-sen University. Zhang Feng from Nanjing Medical University was identified as the most prolific author. The journal published the most articles on this topic. High-frequency keywords included "ferroptosis," "cell death," "hepatocellular carcinoma," "oxidative stress," and "cancer." Our analysis provides insight into the leading countries, institutions, authors, and journals and it highlights recent research hotspots. As an emerging research field, studies on ferroptosis in the liver focused primarily on molecular mechanisms, pathways, and treatment strategies. Hepatocellular carcinoma remains a primary focus within ferroptosis research in the liver. In the future, therapies targeting ferroptosis may offer promising avenues for liver disease treatment.
铁死亡是一种程序性铁依赖性细胞死亡形式，与多种肝脏病理状况相关。最近的研究越来越多地强调了铁死亡在肝功能中的关键作用。本研究旨在通过文献计量分析探讨肝脏疾病中铁死亡的发展情况。我们从科学网（WOS）核心合集检索数据，然后将选定的文章导入VOSviewer、CiteSpace和Microsoft Excel进行知识图谱分析。本研究共纳入1236篇文章，显示过去11年肝脏铁死亡相关出版物稳步增加，近年来有显著激增。中国成为主要贡献者，占全球出版物的86%。主要机构包括浙江大学和中山大学。南京医科大学的张峰被确定为发文量最多的作者。该期刊发表了关于此主题的最多文章。高频关键词包括“铁死亡”“细胞死亡”“肝细胞癌”“氧化应激”和“癌症”。我们的分析提供了对领先国家、机构、作者和期刊的见解，并突出了近期的研究热点。作为一个新兴研究领域，肝脏铁死亡研究主要集中在分子机制、途径和治疗策略上。肝细胞癌仍然是肝脏铁死亡研究的主要焦点。未来，针对铁死亡的疗法可能为肝脏疾病治疗提供有前景的途径。
