Commentary: is trogocytosis relevant for chimeric antigen receptor-T cells?
作者信息
Toolabi Bahareh, Whiteheart Sidney W, Munker Reinhold
机构信息
Division of Hematology and Cellular Therapy, University of Kentucky, Lexington, KY, United States.
Department of Biochemistry, University of Kentucky, Lexington, KY, United States.
出版信息
Oncologist. 2025 Jun 4;30(6). doi: 10.1093/oncolo/oyaf150.
Abstract
摘要
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本文引用的文献
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Antigen escape in CAR-T cell therapy: Mechanisms and overcoming strategies.嵌合抗原受体 T 细胞疗法中的抗原逃逸：机制与克服策略。
Biomed Pharmacother. 2024 Sep;178:117252. doi: 10.1016/j.biopha.2024.117252. Epub 2024 Aug 3.
2
CAR T therapies in multiple myeloma: unleashing the future.嵌合抗原受体 T 细胞疗法在多发性骨髓瘤中的应用：开启未来。
Cancer Gene Ther. 2024 May;31(5):667-686. doi: 10.1038/s41417-024-00750-2. Epub 2024 Mar 4.
3
Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape.CAR 分子的胞吞作用调节 CAR-T 细胞功能障碍和肿瘤抗原逃逸。
Signal Transduct Target Ther. 2023 Dec 25;8(1):457. doi: 10.1038/s41392-023-01708-w.
4
CTLA-4 tail fusion enhances CAR-T antitumor immunity.CTLA-4 尾融合增强 CAR-T 抗肿瘤免疫。
Nat Immunol. 2023 Sep;24(9):1499-1510. doi: 10.1038/s41590-023-01571-5. Epub 2023 Jul 27.
5
Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization.APRIL 和基于抗体片段的骨髓瘤 CAR T 细胞均可通过 trogocytosis 和内化诱导 BCMA 下调。
J Immunother Cancer. 2022 Nov;10(11). doi: 10.1136/jitc-2022-005091.
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KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape.基于 KIR 的抑制性 CAR 可克服 CAR-NK 细胞 trogocytosis 介导的自相残杀和肿瘤逃逸。
Nat Med. 2022 Oct;28(10):2133-2144. doi: 10.1038/s41591-022-02003-x. Epub 2022 Sep 29.
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Oncoimmunology. 2022 Jun 28;11(1):2093426. doi: 10.1080/2162402X.2022.2093426. eCollection 2022.
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Leukemia. 2022 Jul;36(7):1943-1946. doi: 10.1038/s41375-022-01585-2. Epub 2022 Apr 30.
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Cancer Immunol Res. 2021 Oct;9(10):1229-1241. doi: 10.1158/2326-6066.CIR-20-1014. Epub 2021 Jul 29.
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