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Commentary: is trogocytosis relevant for chimeric antigen receptor-T cells?

作者信息

Toolabi Bahareh, Whiteheart Sidney W, Munker Reinhold

机构信息

Division of Hematology and Cellular Therapy, University of Kentucky, Lexington, KY, United States.

Department of Biochemistry, University of Kentucky, Lexington, KY, United States.

出版信息

Oncologist. 2025 Jun 4;30(6). doi: 10.1093/oncolo/oyaf150.

Abstract
摘要

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本文引用的文献

1
Antigen escape in CAR-T cell therapy: Mechanisms and overcoming strategies.
Biomed Pharmacother. 2024 Sep;178:117252. doi: 10.1016/j.biopha.2024.117252. Epub 2024 Aug 3.
2
CAR T therapies in multiple myeloma: unleashing the future.
Cancer Gene Ther. 2024 May;31(5):667-686. doi: 10.1038/s41417-024-00750-2. Epub 2024 Mar 4.
3
Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape.
Signal Transduct Target Ther. 2023 Dec 25;8(1):457. doi: 10.1038/s41392-023-01708-w.
4
CTLA-4 tail fusion enhances CAR-T antitumor immunity.
Nat Immunol. 2023 Sep;24(9):1499-1510. doi: 10.1038/s41590-023-01571-5. Epub 2023 Jul 27.
6
KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape.
Nat Med. 2022 Oct;28(10):2133-2144. doi: 10.1038/s41591-022-02003-x. Epub 2022 Sep 29.
7
Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality.
Oncoimmunology. 2022 Jun 28;11(1):2093426. doi: 10.1080/2162402X.2022.2093426. eCollection 2022.
8
Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion.
Leukemia. 2022 Jul;36(7):1943-1946. doi: 10.1038/s41375-022-01585-2. Epub 2022 Apr 30.
9
Hijacking TYRO3 from Tumor Cells via Trogocytosis Enhances NK-cell Effector Functions and Proliferation.
Cancer Immunol Res. 2021 Oct;9(10):1229-1241. doi: 10.1158/2326-6066.CIR-20-1014. Epub 2021 Jul 29.
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Biting Off What Can Be Chewed: Trogocytosis in Health, Infection, and Disease.
Infect Immun. 2020 Jun 22;88(7). doi: 10.1128/IAI.00930-19.

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