Department of Physiology, University of Toronto , Toronto, Ontario , Canada.
Banting and Best Diabetes Centre, University of Toronto , Toronto, Ontario , Canada.
Am J Physiol Endocrinol Metab. 2018 Mar 1;314(3):E201-E205. doi: 10.1152/ajpendo.00285.2017. Epub 2017 Oct 31.
Recent controversy regarding the therapeutic potential of curcumin indicates the challenges to research in this field. Here, we highlight the investigations of curcumin and other plant-derived polyphenols that demonstrate their application to metabolic diseases, in particular, obesity and diabetes. Thus, a number of preclinical and clinical investigations have shown the beneficial effect of curcumin (and other dietary polyphenols) in attenuating body weight gain, improving insulin sensitivity, and preventing diabetes development in rodent models and prediabetic subjects. Other intervention studies with dietary polyphenols have also found improvements in insulin resistance. Recent studies suggest that the metabolic effects of curcumin/polyphenols are linked to changes in the gut microbiota. Thus, research into curcumin continues to provide novel insights into metabolic regulation that may ultimately translate into effective therapy.
最近关于姜黄素治疗潜力的争议表明了该领域研究所面临的挑战。在这里，我们重点介绍了姜黄素和其他植物来源的多酚的研究，这些研究表明它们可应用于代谢性疾病，特别是肥胖症和糖尿病。因此，许多临床前和临床研究表明，姜黄素（和其他膳食多酚）可减轻体重增加、提高胰岛素敏感性并预防肥胖啮齿动物模型和糖尿病前期患者的糖尿病发展。其他膳食多酚的干预研究也发现了改善胰岛素抵抗的作用。最近的研究表明，姜黄素/多酚的代谢作用与肠道微生物群的变化有关。因此，姜黄素的研究继续为代谢调节提供新的见解，这可能最终转化为有效的治疗方法。
