Pulkkinen E, Soininvaara O
Acta Psychiatr Scand. 1985 Aug;72(2):133-8. doi: 10.1111/j.1600-0447.1985.tb02584.x.
The purpose of the study was to determine whether the total number of days spent in hospital during a 5-year follow-up period could be predicted by determining IgA, IgG and IgM concentrations in 62 schizophrenics on initial admission. A high IgA concentration on initial admission indicated less frequent need for hospital care during follow-up. A scattering diagram of this negative correlation showed that the correlation was based on a group of seven patients whose IgA concentrations markedly exceeded normal values. This group with exceedingly high IgA differed from the control group in several areas, which would indicate that these patients suffer from a "different" schizophrenia than the patients in the control group. This finding supports the idea of the heterogeneity of schizophrenia, and raises the possibility of developing biochemical methods to delineate the diagnostic category of schizophrenia.
该研究的目的是通过测定62例精神分裂症患者初次入院时的IgA、IgG和IgM浓度，来确定能否预测5年随访期内的总住院天数。初次入院时IgA浓度较高表明随访期间对住院治疗的需求较少。这种负相关的散点图显示，这种相关性是基于一组7例患者，他们的IgA浓度明显超过正常值。IgA极高的这组患者在几个方面与对照组不同，这表明这些患者患的是与对照组患者“不同”的精神分裂症。这一发现支持了精神分裂症异质性的观点，并增加了开发生化方法来划分精神分裂症诊断类别的可能性。
