Pulkkinen E
Acta Psychiatr Scand. 1977 Sep;56(3):173-82. doi: 10.1111/j.1600-0447.1977.tb03560.x.
On admission, IgA, IgG and IgM concentrations were determined in 76 schizophrenics, and the correlations of these concentrations to the variables relating to psychopathology, background and prognosis were investigated in the present study, which is a part of a more extensive unpublished study. On the basis of factorization, the highest IgM concentrations were found in withdrawn schizophrenics and the lowest in paranoid schizophrenics. Of the background variables, the patient's present age had a positive correlation and his place of birth (rural-urban) a negative correlation to IgA concentrations, both being at a statistically significant level. IgA and IgM values higher than average at the beginning of treatment predicted a short hospital stay. Earlier, these patients had also needed little hospital care in relation to the duration of the disease. A hypothesis based on the results is presented, according to which a different way of reacting to stress may explain the differences in IgM concentrations in withdrawn and paranoid schizophrenics. The connection between prognosis and immunoglobulins was considered at least partially explainable on the grounds of age at the onset of the disease.
入院时，对76名精神分裂症患者测定了IgA、IgG和IgM浓度，并在本研究中调查了这些浓度与精神病理学、背景及预后相关变量之间的相关性。本研究是一项更广泛的未发表研究的一部分。基于因子分解，发现退缩型精神分裂症患者的IgM浓度最高，偏执型精神分裂症患者的IgM浓度最低。在背景变量中，患者的当前年龄与IgA浓度呈正相关，其出生地（农村-城市）与IgA浓度呈负相关，两者均具有统计学意义。治疗开始时高于平均水平的IgA和IgM值预示着住院时间较短。此前，就疾病持续时间而言，这些患者所需的住院护理也较少。根据研究结果提出了一个假设，据此，对压力的不同反应方式可能解释了退缩型和偏执型精神分裂症患者IgM浓度的差异。预后与免疫球蛋白之间的联系至少部分可以根据疾病发病年龄来解释。
