Chong-Thim W, Wing-Foo T, Nilmani S
Department of Physiology, National University of Singapore.
Schizophr Res. 1993 Jun;10(1):61-6. doi: 10.1016/0920-9964(93)90077-v.
Serum immunoglobulin levels (IgA, IgG and IgM) were determined by an immunoelectrophoretic method in two separate series of Chinese male schizophrenics and healthy controls. In the first series, 41 healthy male blood donors and 98 schizophrenic patients in different stages of the disease were investigated. In the second series a random sample of 50 acutely ill male schizophrenic patients were investigated along with a second group of healthy male subjects. Serum IgG levels were significantly higher in schizophrenics in both the series (p < 0.001). Serum IgA levels were similar in both the patient and control series. Serum IgM levels were significantly higher in schizophrenic patients having acute or severe illness (p < 0.05 and 0.01, respectively). Serum albumin levels were significantly lower in the patients compared to healthy controls. The above changes in immunoglobulins in schizophrenics were not related to duration or dosage of medication with neuroleptic drugs.
采用免疫电泳法测定了两组中国男性精神分裂症患者及健康对照者的血清免疫球蛋白水平（IgA、IgG和IgM）。在第一组中，对41名健康男性献血者和98名处于疾病不同阶段的精神分裂症患者进行了研究。在第二组中，对50名急性发病的男性精神分裂症患者的随机样本以及另一组健康男性受试者进行了研究。在这两组研究中，精神分裂症患者的血清IgG水平均显著升高（p < 0.001）。患者组和对照组的血清IgA水平相似。急性或重症精神分裂症患者的血清IgM水平显著升高（分别为p < 0.05和0.01）。与健康对照相比，患者的血清白蛋白水平显著降低。精神分裂症患者免疫球蛋白的上述变化与抗精神病药物的用药时间或剂量无关。
