Tian Gongwei, Chen Jianhui, Yang Dan, Liang Cuiyuan, Zhao Qinyi, Liu Yan, Lu Weihong, Qi Dianpeng
Key Laboratory of Science and Engineering for the Multi-Modal Prevention and Control of Major Chronic Diseases, Ministry of Industry and Information Technology, Zhengzhou Research Institute of Harbin Institute of Technology, Zhengzhou, 450000, PR China; School of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, PR China.
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, National and Local Joint Engineering Laboratory for Synthesis Transformation and Separation of Extreme Environmental Nutrients, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, PR China.
Talanta. 2025 Dec 1;295:128428. doi: 10.1016/j.talanta.2025.128428. Epub 2025 Jun 3.
Wearable sensing devices provide a promising approach for non-invasive health detection. However, most flexible devices are inevitably susceptible to wear and mechanical degradation in practical applications due to stretching, cutting, or overuse, resulting in device malfunction. Therefore, it is necessary to develop sensing devices with self-healing and stretchable capabilities. Here, an in-situ self-healing and stretchable sweat glucose sensor is fabricated by depositing Au on the synthetic self-healable PDMS-IPDI elastomer and modifying polypyrrole/glucose oxidase on the sensing position, respectively. This sensor can recover electromechanical properties through dynamic hydrogen bonds after fracture and self-healing 4 h at room temperature, and maintain stable sensing properties under 50 % strain, which satisfies the strain required by human skin in daily activities. In addition, the modified polypyrrole film on the Au electrode increases the electrochemically active area of the working electrode by 3-4 times and the sensor exhibits a sensitivity of 62.60 μA mM cm in the linear range of 0-1 mM, with the detection limit is as low as 12.58 μM. Furthermore, the sensor can accurately and reliably detect the glucose content in human sweat samples, providing a novel approach for the practical application of glucose sensors.
可穿戴传感设备为非侵入式健康检测提供了一种很有前景的方法。然而，在实际应用中，大多数柔性设备不可避免地会因拉伸、切割或过度使用而受到磨损和机械降解，从而导致设备故障。因此，有必要开发具有自修复和可拉伸能力的传感设备。在此，通过在合成的可自愈合聚二甲基硅氧烷-异佛尔酮二异氰酸酯（PDMS-IPDI）弹性体上沉积金，并分别在传感位置修饰聚吡咯/葡萄糖氧化酶，制备了一种原位自愈合且可拉伸的汗液葡萄糖传感器。该传感器在断裂后可通过动态氢键恢复机电性能，并在室温下自愈合4小时，在50%应变下保持稳定的传感性能，满足人体皮肤在日常活动中所需的应变。此外，金电极上修饰的聚吡咯膜使工作电极的电化学活性面积增加了3至4倍，该传感器在0至1 mM的线性范围内表现出62.60 μA mM cm的灵敏度，检测限低至12.58 μM。此外，该传感器能够准确可靠地检测人体汗液样本中的葡萄糖含量，为葡萄糖传感器的实际应用提供了一种新方法。
