帕金森病多学科综合治疗(PD-MCT):对其目前在德国治疗帕金森病患者的作用及未来发展需求的认识

Parkinson's Disease Multidisciplinary Complex Therapy (PD-MCT): appreciation of its current function for the treatment of people with Parkinson's disease in Germany and the needs of future development.

作者信息

Scherbaum Raphael, Höllerhage Matthias, Klebe Stephan, Riederer Peter, Müller Thomas, Schröter Nils, Weise David, Woitalla Dirk, Tönges Lars

机构信息

Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, 44791, Bochum, Germany.

Department of Neurology, Hannover Medical School, 30625, Hannover, Germany.

出版信息

J Neural Transm (Vienna). 2025 Jun 12. doi: 10.1007/s00702-025-02963-7.

Abstract

The inpatient Parkinson's Disease Multimodal Complex Therapy (PD-MCT) is a specialized therapeutic concept for people with Parkinson's disease (PD), that is increasingly applied with great success in Germany. It provides a core element of the provision of care for the more than 400,000 PD patients in Germany. In this expert review, we describe the basic elements of PD-MCT in Germany with its structural features, treatment team, therapeutic process and contents. The most recent data on the core neurologic value of PD-MCT are presented with its effect sizes and influencing factors. In detail, eight observational studies have demonstrated relevant effectiveness, with an average improvement of 7.8 points on the Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III. Expert considerations of a PD-MCT target population are depicted as well as its additional values including multidisciplinary assessment and care, differential diagnosis and consideration of comorbidities, patient and caregiver education, improvement of nutrition, polypharmacy and therapeutic drug monitoring. The review concludes with a viewpoint on the possibilities for optimization and the future needs for PD-MCT.

摘要

住院帕金森病多模式综合治疗(PD-MCT)是一种针对帕金森病(PD)患者的专门治疗理念,在德国正越来越多地成功应用。它为德国40多万帕金森病患者提供了护理的核心要素。在这篇专家综述中,我们描述了德国PD-MCT的基本要素,包括其结构特点、治疗团队、治疗过程和内容。介绍了PD-MCT核心神经学价值的最新数据及其效应大小和影响因素。详细而言,八项观察性研究已证明其具有显著疗效,在运动障碍协会统一帕金森病评定量表第三部分上平均提高了7.8分。阐述了对PD-MCT目标人群的专家考量以及其附加价值,包括多学科评估与护理、鉴别诊断和合并症考量、患者及照料者教育、营养改善、联合用药及治疗药物监测。综述最后对PD-MCT的优化可能性和未来需求发表了观点。

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