Arraras Juan Ignacio, Illarramendi Jose Juan, Manterola Ana, de la Cruz Susana, Teijeira Lucia, Pont Angels, Salgado Esteban, Visus Ignacio, Lecumberri Maria Jose, Barrado Marta, de Lascoiti Angela Fernandez, Vera Ruth
Medical Oncology Department. Irunlarrea 3, Hospital Universitario de Navarra, 31008, Pamplona, Spain.
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Clin Transl Oncol. 2025 Jun 12. doi: 10.1007/s12094-025-03962-6.
To study the quality of life of Spanish very long-term early-stage breast cancer survivors, differences between groups based on follow-up duration and global QOL determinants.
Participating in this cross-sectional study were 211 stage I-IIIA-C breast cancer patients from a single centre subjected to breast surgery ≥ 10 years earlier. Patients completed EORTC QLQ-C30 and QLQ-BR45. Patients ≥ 65 years also completed QLQ-ELD14. Comparisons were studied between groups based on the age at assessment (< 70, 71-75 and ≥ 76 years) and years since the beginning of treatment (≤ 15, 16-20 and > 20 years) (both via the Kruskal-Wallis test and the latter adjusted by age). Demographic, clinical and QOL determinants of QLQ-C30 global QOL scale were also studied (linear regression models).
Whole sample QOL scores were high (> 80/100 points) in most areas. Moderate limitations (> 30 points) occurred in QLQ-BR42 in sexual functioning and enjoyment and skeletal symptoms, and in QLQ-ELD14 in worries about others, maintaining purpose and joint stiffness. The ≥ 76 group showed the lowest functioning (physical, sexual, mobility, maintaining purpose), breast satisfaction and family support, and highest fatigue and joint stiffness of the three groups. The > 20 years since beginning of treatment group showed the highest functioning (physical, mobility, and maintaining purpose) and lowest fatigue and joint stiffness. Combining physical functioning, mobility, sleep disturbance, and systemic side effects, R = 60.7.
Quality of life in very long-term early-stage breast cancer patients was high in the whole sample and follow-up groups, indicating patients adapted well to their situation. Results are highly relevant due to the sample's high mean age.
研究西班牙极长期早期乳腺癌幸存者的生活质量、基于随访时长的组间差异以及总体生活质量的决定因素。
本横断面研究纳入了来自单一中心的211例I-IIIA-C期乳腺癌患者，这些患者在至少10年前接受了乳房手术。患者完成了欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）和乳腺癌特异性问卷（QLQ-BR45）。年龄≥65岁的患者还完成了QLQ-ELD14。基于评估时的年龄（<70岁、71-75岁和≥76岁）以及治疗开始后的年份（≤15年、16-20年和>20年）对组间进行比较（均通过Kruskal-Wallis检验，后者按年龄进行调整）。还研究了QLQ-C30总体生活质量量表的人口统计学、临床和生活质量决定因素（线性回归模型）。
在大多数领域，整个样本的生活质量得分较高（>80/100分）。在QLQ-BR42中，性功能和性快感以及骨骼症状方面存在中度限制（>30分），在QLQ-ELD14中，对他人的担忧、保持生活目标和关节僵硬方面存在中度限制。≥76岁组在三组中功能（身体、性、活动能力、保持生活目标）、乳房满意度和家庭支持方面最低，疲劳和关节僵硬程度最高。治疗开始后>20年组功能（身体、活动能力、保持生活目标）最高，疲劳和关节僵硬程度最低。综合身体功能、活动能力、睡眠障碍和全身副作用，R=60.7。
在整个样本和随访组中，极长期早期乳腺癌患者的生活质量较高，表明患者很好地适应了自身状况。由于样本的平均年龄较高, 这些结果具有高度相关性。
