Department of Cardiovascular Medicine, Wenzhou People's Hospital, the Wenzhou Third Clinical Institute Affiliated with Wenzhou Medical University, Wenzhou, Zhe Jiang Province, China.
Department of Inspection Medical, Wenzhou People's Hospital, the Wenzhou Third Clinical Institute Affiliated with Wenzhou Medical University, Wenzhou, Zhe Jiang Province, China.
BMC Pulm Med. 2017 Aug 29;17(1):119. doi: 10.1186/s12890-017-0461-z.
The six-minute walk test (6MWT) is a safe, simple, inexpensive tool for evaluating the functional exercise capacity. However, there is a lack of standard reference equations for the six-minute walk distance (6MWD) in the healthy Chinese Han population with an age of 18-30 years. The aims of the present study were as follows: 1) to measure the anthropometric data and the walking distance in a sample of healthy Chinese Han population, aged 18-30 years; 2) to construct reference equations for the 6MWD; 3) to compare the measured 6MWD of our cohort with previously published equations.
The anthropometric data, demographic, lung function and the walking distance of Chinese Han population, aged 18-30 years, were prospectively measured using a standardized protocol. Informed consent was obtained from each participant and the approval was obtained from the ethics committee of Wenzhou People's Hospital. The 6MWT was performed twice and the longer 6MWD was used for further analysis.
A total of 355 subjects (176 female and 179 male) completed the 6MWT, and the average walking distance was 627.3 ± 52.88 m. The walking distance was achieved by females compared with males (607.4 ± 51.00 m vs. 646.9 ± 47.15 m; p < 0.0001) and active subjects compared with non-active subjects (646.1 ± 48.27 m vs. 611.6 ± 51.52 m; p < 0.0001). Univariate analysis showed age, height, body mass index, resting blood pressure, heart rate and blood pressure after the walk test and difference in heart rate before and after the walk test were significantly correlated with the 6MWD. Stepwise multiple regression analysis showed that height and difference in heart rate before and after the walk test were independent predictors associated with the 6MWD. The reference equations from Caucasian, Canadian and Chilean populations tend to overestimate the walking distance in our subjects, while Brazilian and Arabian equations tend to underestimate the walking distance. There was no significant difference in the walking distance between Korean equations and the current study.
In summary, height and difference in heart rate before and after the walk test were the most significant predictors of the 6MWD, and the regression equations could explain approximately 38% and 31% of the distance variance in the female and male groups, respectively.
六分钟步行测试（6MWT）是一种安全、简单、廉价的评估功能性运动能力的工具。然而，目前缺乏适合 18-30 岁健康汉族人群的 6 分钟步行距离（6MWD）的标准参考方程。本研究的目的如下：1）测量健康汉族人群的人体测量学数据和步行距离，年龄在 18-30 岁之间；2）构建 6MWD 的参考方程；3）比较本队列的测量 6MWD 与之前发表的方程。
前瞻性使用标准化方案测量汉族人群的人体测量学数据、人口统计学、肺功能和步行距离，年龄在 18-30 岁之间。每位参与者均获得知情同意，本研究获得了温州市人民医院伦理委员会的批准。进行了两次 6MWT，使用较长的 6MWD 进行进一步分析。
共有 355 名受试者（176 名女性和 179 名男性）完成了 6MWT，平均步行距离为 627.3±52.88m。女性的步行距离与男性相比（607.4±51.00m 比 646.9±47.15m；p<0.0001），以及与非活动受试者相比（646.1±48.27m 比 611.6±51.52m；p<0.0001）。单因素分析显示，年龄、身高、体重指数、静息血压、心率和步行后血压以及步行前后心率差与 6MWD 显著相关。逐步多元回归分析显示，身高和步行前后心率差是与 6MWD 相关的独立预测因子。来自白种人、加拿大和智利人群的参考方程往往高估了我们受试者的步行距离，而巴西和阿拉伯的方程则往往低估了步行距离。韩国方程与本研究在步行距离方面无显著差异。
综上所述，身高和步行前后心率差是 6MWD 的最重要预测因子，回归方程分别可以解释女性和男性组距离变异的约 38%和 31%。
