Bonnan Mickael
Neurology Department, Hôpital Henri-Mondor, 1 Rue Gustave Eiffel, 94000 Créteil, France.
J Clin Med. 2025 May 28;14(11):3787. doi: 10.3390/jcm14113787.
Thiamine deficiency requires supplementation to prevent or reverse severe clinical complications. Are supplementation protocols correctly tailored in neurology? An examination of recommended thiamine supplementation protocols is undertaken. Recommended thiamine levels are much higher than required, reaching a median daily intake and total amount of 7.8-fold and 30.6-fold greater than the whole-body thiamine store, respectively. The high initial intake is often followed by tapering over days or weeks. Thiamine supplementation protocols in neurology mostly recommend far higher doses than those biologically required and could probably be simplified to a single 100 mg dose injected as early as possible.
硫胺素缺乏需要补充以预防或逆转严重的临床并发症。神经病学领域的补充方案是否经过正确调整？本文对推荐的硫胺素补充方案进行了研究。推荐的硫胺素水平远高于所需水平，每日摄入量中位数和总量分别比全身硫胺素储备高7.8倍和30.6倍。高初始摄入量之后通常会在数天或数周内逐渐减少。神经病学领域的硫胺素补充方案大多推荐远高于生物学所需剂量的剂量，并且可能可以简化为尽早注射单次100毫克剂量。
