Protocols of Thiamine Supplementation: Clinically Driven Rationality vs. Biological Commonsense.

Thiamine deficiency requires supplementation to prevent or reverse severe clinical complications. Are supplementation protocols correctly tailored in neurology? An examination of recommended thiamine supplementation protocols is undertaken. Recommended thiamine levels are much higher than required, reaching a median daily intake and total amount of 7.8-fold and 30.6-fold greater than the whole-body thiamine store, respectively. The high initial intake is often followed by tapering over days or weeks. Thiamine supplementation protocols in neurology mostly recommend far higher doses than those biologically required and could probably be simplified to a single 100 mg dose injected as early as possible.