Melinte Oana-Elena, Stavarache Emanuel Ioan, Dobrin Mona Elisabeta, Cernomaz Andrei Tudor, Cioroiu Ionel-Bogdan, Popa Daniela Robu, Grosu-Creanga Ionela-Alina, Zabara Antal Andreea, Trofor Antigona Carmen
Discipline of Pneumology, III-rd Medical Department, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Biochemistry Department, Clinical Hospital of Pulmonary Diseases, 700116 Iasi, Romania.
J Clin Med. 2025 Jun 5;14(11):4007. doi: 10.3390/jcm14114007.
Asthma is a chronic inflammatory airway disease in which oxidative stress and antioxidant imbalance play a critical role in disease progression and therapeutic response. This study aimed to evaluate oxidative stress and antioxidant status in relation to asthma control levels. : A total of 106 patients admitted to the Clinical Hospital of Pulmonary Diseases, Iași, between March and May 2024 were included in this study. Patients were classified into three groups based on asthma control: well-controlled (AB-TCG), partially controlled (AB-PCG), and uncontrolled asthma (AB-UCG). Demographic, biochemical, and hematological parameters were assessed, with attention to oxidative stress markers and antioxidant defenses. : The study population was predominantly female (75%), with a mean age ranging from 50.75 to 64.38 years, and the majority residing in rural areas (73-75%). The AB-UCG group showed significantly elevated inflammatory markers, including a white blood cell count of 9.33 × 10/µL ( = 0.005) and eosinophil percentage of 4.20% ( = 0.03), compared with the other groups. This group also exhibited an unfavorable lipid profile, with increased total cholesterol (207.40 mg/dL) and triglyceride levels (157.21 mg/dL). Oxidative stress was notably higher in the AB-UCG group, as indicated by elevated malondialdehyde (MDA) levels (2.86 mmol/L) versus 2.35 mmol/L in the AB-PCG group ( < 0.005), along with decreased serum uric acid (4.64 mg/dL) and reduced glutathione (GSH) levels (275.41 µmol/L), leading to a lower GSH/GSSG ratio. Environmental exposures, including tobacco smoke and occupational chemicals, were associated with exacerbated oxidative imbalance. The findings highlight the critical involvement of oxidative stress and compromised antioxidant defenses in poorly controlled asthma. Biomarkers such as MDA, white blood cell count, eosinophil percentage, and the GSH/GSSG ratio may act as valuable tools for personalized asthma management and therapeutic monitoring.
哮喘是一种慢性炎症性气道疾病，其中氧化应激和抗氧化失衡在疾病进展和治疗反应中起关键作用。本研究旨在评估与哮喘控制水平相关的氧化应激和抗氧化状态。2024年3月至5月期间，共有106名入住雅西肺病临床医院的患者纳入本研究。根据哮喘控制情况，患者被分为三组：控制良好组（AB-TCG）、部分控制组（AB-PCG）和未控制哮喘组（AB-UCG）。评估了人口统计学、生化和血液学参数，重点关注氧化应激标志物和抗氧化防御。研究人群以女性为主（75%），平均年龄在50.75至64.38岁之间，大多数居住在农村地区（73 - 75%）。与其他组相比，AB-UCG组的炎症标志物显著升高，包括白细胞计数为9.33×10/µL（P = 0.005）和嗜酸性粒细胞百分比为4.20%（P = 0.03）。该组还表现出不利的血脂谱，总胆固醇（207.40 mg/dL）和甘油三酯水平升高（157.21 mg/dL）。AB-UCG组的氧化应激明显更高，丙二醛（MDA）水平升高（2.86 mmol/L），而AB-PCG组为2.35 mmol/L（P < 0.005），同时血清尿酸降低（4.64 mg/dL）和谷胱甘肽（GSH）水平降低（275.41 µmol/L），导致GSH/GSSG比值降低。包括烟草烟雾和职业化学品在内的环境暴露与氧化失衡加剧有关。研究结果突出了氧化应激和抗氧化防御受损在控制不佳的哮喘中的关键作用。诸如MDA、白细胞计数、嗜酸性粒细胞百分比和GSH/GSSG比值等生物标志物可能作为个性化哮喘管理和治疗监测的有价值工具。
