Cheng Chi-Feng, Nguyen Thi Kim Ngan, Shen Szu-Chuan, Chen Bo-Yu, Wu Yeh-B, Liang Hui-Ju, Wu Chung-Hsin
Department of Oncology, Ren Ai Branch, Taipei City Hospital, Taipei 10629, Taiwan.
School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Int J Mol Sci. 2025 May 27;26(11):5136. doi: 10.3390/ijms26115136.
The gut microbiome supports immune health and influences gut and heart functions through the gut-heart axis. Synbiotics (SBT), combining probiotics and prebiotics, help restore microbiome balance. Chemotherapy often disrupts this balance, leading to adverse effects on the gut and heart. This study explores the potential of SBT supplementation in reducing heart and gut inflammation caused by doxorubicin (DOX) chemotherapy. The gut microbiome plays a vital role in immune health, and metabolites produced by gut bacteria contribute to physiological functions through the gut-heart axis. Chemotherapy drugs often disrupt these processes, leading to adverse effects on internal organs. Using 24 ICR male mice divided into four groups, the experiment assessed the impact of SBT on DOX-induced damage. Results indicated that DOX treatment significantly worsened survival rates, physical performance, heart function, and gut microbiome stability. However, co-treatment with SBT improved these markers, suggesting that SBT may help mitigate chemotherapy-induced side effects in cancer patients.
肠道微生物群有助于免疫健康，并通过肠-心轴影响肠道和心脏功能。合生元（SBT）结合了益生菌和益生元，有助于恢复微生物群平衡。化疗常常会破坏这种平衡，从而对肠道和心脏产生不良影响。本研究探讨了补充SBT在减轻阿霉素（DOX）化疗引起的心脏和肠道炎症方面的潜力。肠道微生物群在免疫健康中起着至关重要的作用，肠道细菌产生的代谢产物通过肠-心轴促进生理功能。化疗药物常常会破坏这些过程，从而对内脏产生不良影响。该实验使用24只雄性ICR小鼠，分为四组，评估了SBT对DOX诱导损伤的影响。结果表明，DOX治疗显著降低了存活率、身体机能、心脏功能和肠道微生物群稳定性。然而，SBT联合治疗改善了这些指标，表明SBT可能有助于减轻癌症患者化疗引起的副作用。
