Velásquez José, Fuentealba Melani, Santibáñez Mauricio
Departamento de Cs. Físicas, Universidad de La Frontera, Temuco 4811230, Chile.
Laboratorio de Radiaciones Ionizantes, Universidad de La Frontera, Temuco 4811230, Chile.
Polymers (Basel). 2025 May 28;17(11):1496. doi: 10.3390/polym17111496.
This study presents a comprehensive dosimetric characterization and commissioning of a grid-type collimator manufactured via 3D printing using PLA-W composite filament, following an international protocol for small-field dosimetry. PLA doped with high concentrations of tungsten (>90% /) enables the fabrication of miniaturized collimators (<1 cm) with complex geometries, suitable for non-conventional radiotherapy applications. However, accurate assessment of spatial dose modulation is challenged by penumbra overlap between closely spaced beamlets, limiting the application of conventional instrumentation and protocols. To address this, absolute and relative dose distributions were evaluated for various radiation field configurations (number of beamlets) in both lateral and depth directions. Measurements were performed according to the IAEA TRS-483 protocol, using micro-ionization chambers and diode detectors. Additionally, long-term stability assessments were carried out to evaluate both the structural integrity and modulation performance of the printed grid over time. Point dose measurements using the same detectors were repeated after one year, and 2D surface dose distributions measured with EBT3 films were compared to SRS MapCHECK measurements two years later. The generated radiation field size of the central beamlet (FWHM) differed by less than 0.2% (15.8 mm) from the physical projection size (15.6 mm) and the lateral transmission due simultaneous beamlets resulted in FWHM variations of less than 3.8%, confirming manufacturing precision and collimator capability. Output factor measurements increased with the number of beamlets, from 0.75 for a single beamlet to 0.82 for the full beamlets configuration. No significant changes were observed in the depth of maximum dose across the different beamlets configurations (1.20 ± 0.20 cm). On the other hand, the long-term evaluations show no relevant changes in the FWHM or VPR, confirming the performance and reliability of the system. These results support the clinical feasibility and lasting performance stability of in-house manufactured grid collimators using PLA-W filaments and accessible 3D printing technology.
本研究按照小射野剂量学的国际协议,对使用聚乳酸-钨(PLA-W)复合长丝通过3D打印制造的格栅型准直器进行了全面的剂量学表征和调试。掺杂高浓度钨(>90% /)的聚乳酸能够制造出具有复杂几何形状的小型化准直器(<1厘米),适用于非常规放射治疗应用。然而,紧密间隔的子束之间的半影重叠对空间剂量调制的准确评估提出了挑战,限制了传统仪器和协议的应用。为解决这一问题,在横向和深度方向上对各种辐射野配置(子束数量)的绝对和相对剂量分布进行了评估。根据国际原子能机构(IAEA)TRS-483协议,使用微型电离室和二极管探测器进行测量。此外,还进行了长期稳定性评估,以评估打印格栅随时间的结构完整性和调制性能。一年后使用相同探测器重复进行点剂量测量,并将两年后用EBT3胶片测量的二维表面剂量分布与SRS MapCHECK测量结果进行比较。中心子束产生的辐射野尺寸(半高宽)与物理投影尺寸(15.6毫米)相差不到0.2%(15.8毫米),同时子束导致的横向透射使半高宽变化小于3.8%,证实了制造精度和准直器能力。输出因子测量值随子束数量增加,从单个子束的0.75增加到全子束配置的0.82。在不同子束配置下,最大剂量深度未观察到显著变化(1.20±0.20厘米)。另一方面,长期评估表明半高宽或体积通过率无相关变化,证实了系统的性能和可靠性。这些结果支持了使用PLA-W长丝和可及的3D打印技术在内部制造格栅准直器的临床可行性和持久性能稳定性。