Liu G, Zhang L, Zhao H, Deng S, Yang J, Li N, Ma R, He Y, Xu G, Liu Z, Zhan S
Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, Zhejiang, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2025 Jun 18;57(3):584-591. doi: 10.19723/j.issn.1671-167X.2025.03.024.
To describe the epidemiological characteristics and changes of febrile seizure (FS) among children under 6 years old in Ningbo City, Zhejiang Province from 2015 to 2021.
Based on the Ningbo Regional Health Information Platform, a dynamic cohort was established using vaccination registration information, and the cases of FS were identified by the diagnostic results of Chinese terms or International Classification of Diseases 10th revision (ICD-10) R56.0 code in the electronic medical records. The first visit of FS during the observation period was defined as a new case, and a recurrence case was defined as the case with a visit interval of more than 7 days. The 95% confidence interval () of FS incidence density was calculated by the Poisson distribution.
From January 2015 to June 2020, there were 1.3 million children under 6 years old in Ningbo, with male accounting for 52.87%. The median follow-up time was 2.83 (1.55-4.00) years. During the follow-up period, 12 776 new onset cases had FS, with more males than females, with an overall incidence density of 4.34 (95% 4.27-4.40)/1 000 person-years and a recurrence rate of 21.63%. There was a higher incidence density in children who were male, born in Ningbo and of non-mobility. The incidence density of FS was higher in urban areas than in rural and rural-urban fringe areas, and the incidence density was different among districts and counties. The peak density was found in children aged 18-23 months [8.42 (95% 8.11-8.74)/1 000 person-years]. From 2015 to 2019, the incidence density increased with calendar year ( < 0.001), and the highest was 5.62 (95% 5.43-5.81) /1 000 person-years. The incidence density of FS decreased significantly during the period between 2020 and 2021. The incidence density was higher in winter.
From 2015 to 2019, the overall incidence density of FS in children under 6 years old in Ningbo City presented an increasing trend. More attention should be paid to the health education, the improvement of the health maintenance model, the enhancement of the cognition of FS, the identification and treatment of FS among high-risk population and regions so as to prevent its recurrence and reduce the disease burden during the corona virus disease 2019 (COVID-19) epide-mic.
描述2015年至2021年浙江省宁波市6岁以下儿童热性惊厥（FS）的流行病学特征及变化情况。
基于宁波市区域卫生信息平台，利用疫苗接种登记信息建立动态队列，通过电子病历中的中文诊断结果或国际疾病分类第10版（ICD - 10）R56.0编码识别FS病例。将观察期内FS的首次就诊定义为新发病例，就诊间隔超过7天的病例定义为复发病例。采用泊松分布计算FS发病密度的95%置信区间（）。
2015年1月至2020年6月，宁波市6岁以下儿童共130万，男性占52.87%。中位随访时间为2.83（1.55 - 4.00）年。随访期间，新发FS病例12776例，男性多于女性，总体发病密度为4.34（95% 4.27 - 4.40）/1000人年，复发率为21.63%。男性、在宁波出生及非流动人口中的儿童发病密度较高。FS发病密度城区高于农村及城乡结合部地区，各区县之间发病密度也存在差异。发病密度高峰出现在18 - 23个月龄儿童[8.42（95% 8.11 - 8.74）/1000人年]。2015年至2019年，发病密度随年份增加（< 0.001），最高为5.62（95% 5.43 - 5.81）/1000人年。2020年至2021年期间FS发病密度显著下降。冬季发病密度较高。
2015年至2019年，宁波市6岁以下儿童FS总体发病密度呈上升趋势。应更加关注健康教育、健康维护模式的改善、对FS的认知提升、高危人群和地区FS的识别与治疗，以预防其复发并减轻2019冠状病毒病（COVID - 19）疫情期间的疾病负担。
