Senanayake Dinithi, Yapa Piumika, Dabare Sanduni, Munaweera Imalka, Weerasekera Manjula M, Etampawala Thusitha N B, Sethunga Maheshika, Attygalle Dinesh, Amarasinghe Shantha
Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura Nugegoda 10250 Sri Lanka
Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura Nugegoda 10250 Sri Lanka
RSC Adv. 2025 Jun 12;15(25):20061-20083. doi: 10.1039/d5ra01642h. eCollection 2025 Jun 10.
The increasing risk of microbial infections and antimicrobial resistance requires the development of sustainable biomaterials with improved therapeutic properties for effective and environmentally friendly health and safety applications, leading to the exploration of advanced multifunctional nanomaterials. This study introduces a novel electrospun polymeric membrane that integrates a trimetallic nanohybrid composed of silver (Ag), copper (Cu), and nickel (Ni) with curcuminoids derived from turmeric oleoresin. This combination is incorporated into a biodegradable polycaprolactone (PCL) electrospun mat. The synthesis and characterization of the nanohybrids were performed using Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV diffuse reflectance spectrometry. The electrospun membranes incorporated with a trimetallic and curcuminoids nanohybrid demonstrated a synergistic antimicrobial effect, as evidenced by inhibition zones measuring between 29.67 ± 0.24 and 33.17 ± 0.24 mm against a wide range of bacterial and fungal strains. The primary antimicrobial mechanism is attributed to radical scavenging activity (RSA), which reached a maximum value of 76.14 ± 0.99% in the trimetallic and curcuminoids nanohybrid incorporated PCL mat. Furthermore, the curcuminoids displayed significant anti-inflammatory effects, achieving a maximum reduction of 72.81 ± 0.33% at a concentration of 5000 ppm. The electrospun membranes effectively reduce microbial growth, are biodegradable, non-toxic, pose minimal hazards, and are environmentally friendly, aligning with sustainable technologies for biomedical applications. These membranes function as physical and biological barriers, offering an eco-conscious, cost-effective alternative to conventional antimicrobial strategies. This research highlights the potential of trimetallic-curcuminoid nanohybrid electrospun membranes as sustainable biomaterials for advanced antimicrobial treatments, contributing to safer and more effective biomedical applications while ensuring biocompatibility and environmental safety. It exemplifies how innovative solutions can tackle health and sustainability challenges.
微生物感染风险和抗菌耐药性的不断增加，需要开发具有改进治疗特性的可持续生物材料，以用于有效且环保的健康与安全应用，从而促使人们探索先进的多功能纳米材料。本研究介绍了一种新型的电纺聚合物膜，该膜将由银（Ag）、铜（Cu）和镍（Ni）组成的三金属纳米杂化物与姜黄提取物中的姜黄素类物质相结合，并将这种组合掺入可生物降解的聚己内酯（PCL）电纺垫中。使用傅里叶变换红外光谱（FTIR）、拉曼光谱、X射线衍射（XRD）、扫描电子显微镜（SEM）和紫外漫反射光谱对纳米杂化物进行了合成与表征。掺入三金属和姜黄素类纳米杂化物的电纺膜表现出协同抗菌作用，对多种细菌和真菌菌株的抑菌圈在29.67±0.24至33.17±0.24毫米之间，这证明了该协同抗菌作用。主要抗菌机制归因于自由基清除活性（RSA），在掺入三金属和姜黄素类纳米杂化物的PCL垫中，自由基清除活性达到最大值76.14±0.99%。此外，姜黄素类物质显示出显著的抗炎作用，在浓度为5000 ppm时最大减少率达到72.81±0.33%。电纺膜能有效减少微生物生长，具有可生物降解、无毒、危害最小且环保的特点，符合生物医学应用的可持续技术要求。这些膜作为物理和生物屏障，为传统抗菌策略提供了一种具有生态意识且经济高效的替代方案。本研究突出了三金属 - 姜黄素类纳米杂化物电纺膜作为先进抗菌治疗的可持续生物材料的潜力，有助于实现更安全、更有效的生物医学应用，同时确保生物相容性和环境安全。它例证了创新解决方案如何应对健康与可持续性挑战。
