Franck Linda S, Lemmon Monica E, Grossbauer Lisa, Pawlowski Kamil, Sturza Julie S, Wusthoff Courtney J, Massey Shavonne L, Chu Catherine J, Soul Janet S, Numis Adam L, Thomas Cameron, Benedetti Giulia M, Anwar Tayyba, Berl Madison M, Gidley Larson Jennifer C, Rogers Elizabeth E, Chen Carmen, McCulloch Charles E, Glass Hannah C, Shellhaas Renée A
Department of Family Health Care Nursing, University of California San Francisco, San Francisco, CA.
Departments of Pediatrics and Population Health Sciences, Duke University, School of Medicine, Durham, NC.
J Pediatr Clin Pract. 2025 May 16;16:200149. doi: 10.1016/j.jpedcp.2025.200149. eCollection 2025 Jun.
To assess parent/family well-being when children with neonatal seizures reach 3-8 years of age and examine factors associated with parent/family well-being.
One parent per surviving infant in the Neonatal Seizure Registry-II was invited to complete validated surveys annually when children were between 3 and 8 years of age. Three outcomes were examined: (1) parent well-being (anxiety, depression, and quality of life); (2) parent post-traumatic stress symptoms; and (3) impact on the family. We used mixed model regression with random intercepts and guided backward elimination and included potential predictors that had bivariate associations < .10 in the multivariable analyses.
Among 169 parents, 8%-35% experienced symptoms of anxiety, depression, or post-traumatic stress. When children were 8 years of age, about 1 in 3 parents had moderate to severe anxiety symptoms, approximately double the general population, 1 in 5 had post-traumatic stress disorder symptoms and depression symptom frequency was similar to the general population in the final models, only child social communication impairment was associated with poorer parental well-being or post-traumatic stress symptoms. Several child factors, including age at discharge from the neonatal admission, functional impairment at 24 months, social communication impairment, and receiving special services, were associated with greater impact on the family.
Child social and functional health challenges following neonatal seizures were associated with poorer parent and family well-being across the preschool and early school years. Longitudinal screening of child social functioning, parent well-being, and family function is indicated for early detection and referral to treatment services.
Clinical Trial Registration:NCT04337697.
评估新生儿癫痫患儿3至8岁时家长/家庭的幸福感，并研究与家长/家庭幸福感相关的因素。
邀请新生儿癫痫登记处-II中每个存活婴儿的一位家长，在孩子3至8岁时每年完成经过验证的调查问卷。研究了三个结果：（1）家长幸福感（焦虑、抑郁和生活质量）；（2）家长创伤后应激症状；（3）对家庭的影响。我们使用了具有随机截距的混合模型回归和向后逐步淘汰法，并纳入了在多变量分析中双变量关联<0.10的潜在预测因素。
在169位家长中，8%-35%经历过焦虑、抑郁或创伤后应激症状。当孩子8岁时，约三分之一的家长有中度至重度焦虑症状，约为普通人群的两倍，五分之一有创伤后应激障碍症状，抑郁症状发生率在最终模型中与普通人群相似，只有儿童社交沟通障碍与较差的家长幸福感或创伤后应激症状相关。几个儿童因素，包括新生儿住院出院时的年龄、24个月时的功能障碍、社交沟通障碍和接受特殊服务，与对家庭的更大影响相关。
新生儿癫痫后儿童的社交和功能健康挑战与学前和小学早期较差的家长和家庭幸福感相关。建议对儿童社交功能、家长幸福感和家庭功能进行纵向筛查，以便早期发现并转介至治疗服务。
临床试验注册：NCT04337697。
