用于评估磁热疗中粒子能量的纳米磁性模型的综合分析。
A comprehensive analysis of nanomagnetism models for the evaluation of particle energy in magnetic hyperthermia.
作者信息
Maniotis N, Maragakis M, Vordos N
机构信息
Department of Physics, Aristotle University of Thessaloniki Thessaloniki Greece
Department of Physics, Democritus University of Thrace Kavala Greece.
出版信息
Nanoscale Adv. 2025 May 27. doi: 10.1039/d5na00258c.
Magnetic nanoparticles (MNPs) have attracted significant research interest due to their unique magnetic properties, which differ from their bulk counterparts and enable applications in information technology, environmental protection, and biomedicine. Among these applications, magnetic particle hyperthermia (MPH) has emerged as a promising therapeutic approach for cancer treatment. This review provides a comprehensive analysis of nanomagnetism models used to evaluate the heating potential of MNPs in MPH. Specifically, we examine (i) theoretical approaches for estimating the magnetic properties of nanoparticle systems and (ii) numerical simulation strategies that predict their response to externally applied magnetic fields. Common modeling frameworks typically focus on key magnetic parameters such as total energy, magnetization, anisotropy, and hysteresis loop morphology. However, precise characterization of these properties remains challenging due to their dependence on multiple interrelated factors, including particle size, shape, composition, and interparticle interactions. To address these challenges, this review discusses various analytical and numerical models that aid in the qualitative and quantitative assessment of MNP behavior under alternating magnetic fields. By critically evaluating these methodologies, we aim to enhance the understanding of magnetic field-driven heating mechanisms and contribute to the optimization of MNPs for hyperthermia-based therapeutic applications. Looking forward, the integration of advanced multiphysics simulations, combining magnetization dynamics with biological, thermal, and fluidic environments, is anticipated to revolutionize the predictive accuracy and translational potential of MPH technologies.
磁性纳米颗粒(MNPs)因其独特的磁性而引起了广泛的研究兴趣,这种磁性与它们的块状对应物不同,使其能够应用于信息技术、环境保护和生物医学领域。在这些应用中,磁热疗(MPH)已成为一种有前景的癌症治疗方法。本文综述对用于评估MPH中MNPs加热潜力的纳米磁性模型进行了全面分析。具体而言,我们研究了(i)估计纳米颗粒系统磁性特性的理论方法,以及(ii)预测其对外加磁场响应的数值模拟策略。常见的建模框架通常关注诸如总能量、磁化强度、各向异性和磁滞回线形态等关键磁性参数。然而,由于这些特性依赖于多个相互关联的因素,包括颗粒大小、形状、组成和颗粒间相互作用,因此对这些特性进行精确表征仍然具有挑战性。为应对这些挑战,本文综述讨论了各种有助于定性和定量评估交变磁场下MNPs行为的分析和数值模型。通过严格评估这些方法,我们旨在加深对磁场驱动加热机制的理解,并为基于热疗的治疗应用优化MNPs做出贡献。展望未来,将磁化动力学与生物、热和流体环境相结合的先进多物理场模拟有望彻底改变MPH技术的预测准确性和转化潜力。