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用于精准医学的磁性纳米颗粒的多功能效应:结合磁颗粒热成像和热疗

Multifunctional effects in magnetic nanoparticles for precision medicine: combining magnetic particle thermometry and hyperthermia.

作者信息

Barrera Gabriele, Allia Paolo, Tiberto Paola

机构信息

INRiM, Advanced Materials Metrology and Life Sciences Torino I-10135 Italy

出版信息

Nanoscale Adv. 2023 Jul 5;5(16):4080-4094. doi: 10.1039/d3na00197k. eCollection 2023 Aug 8.

DOI:10.1039/d3na00197k
PMID:37560417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10408592/
Abstract

An effective combination of magnetic hyperthermia and thermometry is shown to be implementable by using magnetic nanoparticles which behave either as a heat sources or as temperature sensors when excited at two different frequencies. Noninteracting magnetite nanoparticles are modeled as double-well systems and their magnetization is obtained by solving rate equations. Two temperature sensitive properties derived from the cyclic magnetization and exhibiting a linear dependence on temperature are studied and compared for monodisperse and polydisperse nanoparticles. The multifunctional effects enabling the combination of magnetic hyperthermia and thermometry are shown to depend on the interplay among nanoparticle size, intrinsic magnetic properties and driving-field frequency. Magnetic hyperthermia and thermometry can be effectively combined by properly tailoring the magnetic properties of nanoparticles and the driving-field frequencies.

摘要

研究表明,通过使用磁性纳米颗粒,可实现磁热疗与温度测量的有效结合,这些磁性纳米颗粒在两种不同频率激发时,既可以作为热源,也可以作为温度传感器。非相互作用的磁铁矿纳米颗粒被建模为双阱系统,其磁化强度通过求解速率方程获得。研究了从循环磁化强度导出的、对温度呈线性依赖的两种温度敏感特性,并对单分散和多分散纳米颗粒进行了比较。结果表明,实现磁热疗与温度测量相结合的多功能效应取决于纳米颗粒尺寸、固有磁性和驱动场频率之间的相互作用。通过适当调整纳米颗粒的磁性和驱动场频率,可以有效地将磁热疗与温度测量结合起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/d4c8fdac0d84/d3na00197k-f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/c7654bc1b896/d3na00197k-f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/d4c8fdac0d84/d3na00197k-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/226673301d6b/d3na00197k-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/b49ee245fc50/d3na00197k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/5d662c1b086f/d3na00197k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/d56b97727c7d/d3na00197k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/c7654bc1b896/d3na00197k-f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b65/10408592/d4c8fdac0d84/d3na00197k-f10.jpg

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