Khan Mariyam, More Akash, Choudhary Namrata, Chaudhary Aru
Department of Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (Meghe), Wardha, Maharashtra, India.
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S997-S999. doi: 10.4103/jpbs.jpbs_344_25. Epub 2025 Apr 29.
This case study involved a 28-year-old woman with primary infertility, chronic abnormal vaginal bleeding, recurrent miscarriages, and uterine polyps. After undergoing hysteroscopic polypectomy to remove the polyps, plasma rich in growth factors PRGF) therapy was administered to enhance endometrial thickness. Following the therapy, the endometrial thickness increased to 7 mm, leading to successful implantation and a positive pregnancy outcome. PRGF therapy was integrated into the fertilization (IVF) process, including ovum pickup, intracytoplasmic sperm injection (ICSI), and embryo transfer. PRGF releases growth factors, such as platelet-derived growth factor and transformation growth factor (TGF-β1), which play key roles in repairing endometrial tissue, promoting cell proliferation, and enhancing the function of primary cells involved in tissue regeneration. Although the short-term results in this case are promising, further research is necessary to investigate the long-term effects of PRGF therapy on IVF outcomes, including implantation success, biochemical pregnancies, and ongoing pregnancies. PRGF therapy shows promise as a complementary treatment in IVF protocols, particularly for patients with thin endometrial linings or uterine polyps. It offers a safe, minimally invasive, and cost-effective approach to improving endometrial receptivity and enhancing IVF success rates. However, further studies are needed to validate its long-term efficacy and its role in improving overall reproductive outcomes.
本案例研究涉及一名28岁的原发性不孕女性，她患有慢性异常阴道出血、复发性流产和子宫息肉。在接受宫腔镜息肉切除术以切除息肉后，给予富含生长因子的血浆（PRGF）治疗以增加子宫内膜厚度。治疗后，子宫内膜厚度增加到7毫米，从而实现了成功着床并获得了阳性妊娠结果。PRGF治疗被纳入体外受精（IVF）过程，包括取卵、卵胞浆内单精子注射（ICSI）和胚胎移植。PRGF释放生长因子，如血小板衍生生长因子和转化生长因子（TGF-β1），这些生长因子在修复子宫内膜组织、促进细胞增殖以及增强参与组织再生的原代细胞功能方面发挥着关键作用。尽管该案例的短期结果很有前景，但有必要进一步研究PRGF治疗对IVF结局的长期影响，包括着床成功、生化妊娠和持续妊娠。PRGF治疗有望作为IVF方案中的一种辅助治疗方法，特别是对于子宫内膜薄或有子宫息肉的患者。它提供了一种安全、微创且经济有效的方法来提高子宫内膜容受性并提高IVF成功率。然而，需要进一步研究来验证其长期疗效及其在改善整体生殖结局中的作用。
