The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Department of General Practice, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Front Endocrinol (Lausanne). 2023 Dec 13;14:1273542. doi: 10.3389/fendo.2023.1273542. eCollection 2023.
Polycystic ovarian syndrome (PCOS) is a metabolic, reproductive, and psychological disorder affecting 6-20% of reproductive women worldwide. However, there is still no cure for PCOS, and current treatments primarily alleviate its symptoms due to a poor understanding of its etiology. Compelling evidence suggests that hyperandrogenism is not just a primary feature of PCOS. Instead, it may be a causative factor for this condition. Thus, figuring out the mechanisms of androgen synthesis, conversion, and metabolism is relatively important. Traditionally, studies of androgen excess have largely focused on classical androgen, but in recent years, adrenal-derived 11-oxygenated androgen has also garnered interest. Herein, this Review aims to investigate the origins of androgen excess, androgen synthesis, how androgen receptor (AR) signaling mediates adverse PCOS traits, and the role of 11-oxygenated androgen in the pathophysiology of PCOS. In addition, it provides therapeutic strategies targeting hyperandrogenism in PCOS.
多囊卵巢综合征（PCOS）是一种影响全球 6-20%育龄女性的代谢、生殖和心理疾病。然而，目前仍然没有治愈 PCOS 的方法，由于对其病因的认识不足，当前的治疗方法主要是缓解其症状。有强有力的证据表明，高雄激素血症不仅仅是 PCOS 的主要特征，它可能是导致这种疾病的一个因素。因此，弄清楚雄激素的合成、转化和代谢机制相对重要。传统上，雄激素过多的研究主要集中在经典的雄激素上，但近年来，肾上腺衍生的 11-氧化雄激素也引起了关注。本文综述旨在探讨雄激素过多的起源、雄激素的合成、雄激素受体（AR）信号如何介导不良的 PCOS 特征，以及 11-氧化雄激素在 PCOS 病理生理学中的作用。此外，它还提供了针对 PCOS 高雄激素血症的治疗策略。
