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Pyridoxamine does not reduce arterial stiffness in an 8-week randomized double-blind placebo-controlled intervention trial with abdominally obese individuals.

作者信息

Van den Eynde Mathias D G, van der Bruggen Myrthe M, Houben Alfons J H M, Reesink Koen D, Spronck Bart, Delhaas Tammo, Scheijen Jean J L J M, Miyata Toshio, Schalkwijk Casper G

机构信息

Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands.

Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

出版信息

Diabetes Obes Metab. 2025 Sep;27(9):5332-5336. doi: 10.1111/dom.16524. Epub 2025 Jun 13.

DOI:10.1111/dom.16524
PMID:40511484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12326883/
Abstract
摘要

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本文引用的文献

1
Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial.吡哆胺可降低甲基乙二醛和糖基化及血管内皮功能障碍的标志物，但不能改善腹型肥胖者的胰岛素敏感性或血管功能：一项随机、双盲、安慰剂对照试验。
Diabetes Obes Metab. 2023 May;25(5):1280-1291. doi: 10.1111/dom.14977. Epub 2023 Feb 14.
2
Pyridoxamine treatment ameliorates large artery stiffening and cerebral artery endothelial dysfunction in old mice.吡哆胺治疗可改善老年小鼠大动脉僵硬和脑动脉内皮功能障碍。
J Cereb Blood Flow Metab. 2023 Feb;43(2):281-295. doi: 10.1177/0271678X221130124. Epub 2022 Oct 2.
3
Mechanisms underlying the blood pressure-lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial.恩格列净、氯沙坦及其联合治疗 2 型糖尿病患者的降压作用机制：一项随机交叉试验的二次分析。
Diabetes Obes Metab. 2023 Jan;25(1):198-207. doi: 10.1111/dom.14864. Epub 2022 Sep 27.
4
Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases.甲基乙二醛，一种高反应性二羰基化合物，在糖尿病及其血管并发症和其他与年龄相关的疾病中的作用。
Physiol Rev. 2020 Jan 1;100(1):407-461. doi: 10.1152/physrev.00001.2019. Epub 2019 Sep 20.
5
Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease and Mortality in Individuals With Type 2 Diabetes.血浆甲基乙二醛水平升高与 2 型糖尿病患者心血管疾病事件和死亡风险增加相关。
Diabetes Care. 2018 Aug;41(8):1689-1695. doi: 10.2337/dc18-0159. Epub 2018 May 21.
6
Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study.血浆甲基乙二醛水平升高与 1 型糖尿病患者心血管疾病事件的发生相关：一项为期 12 年的随访研究。
Diabetes. 2017 Aug;66(8):2278-2283. doi: 10.2337/db16-1578. Epub 2017 Jun 6.
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Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening: The Maastricht Study.皮肤自发荧光和戊糖苷与主动脉硬化相关：马斯特里赫特研究。
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Diabetes. 2016 Apr;65(4):956-66. doi: 10.2337/db15-1390. Epub 2015 Dec 30.
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Glucosepane and oxidative markers in skin collagen correlate with intima media thickness and arterial stiffness in long-term type 1 diabetes.皮肤胶原蛋白中的葡糖胺聚糖和氧化标志物与长期1型糖尿病患者的内膜中层厚度及动脉僵硬度相关。
J Diabetes Complications. 2015 Apr;29(3):407-12. doi: 10.1016/j.jdiacomp.2014.12.011. Epub 2014 Dec 29.
10
Reduction of advanced-glycation end products levels and inhibition of RAGE signaling decreases rat vascular calcification induced by diabetes.降低晚期糖基化终末产物水平并抑制RAGE信号传导可减少糖尿病诱导的大鼠血管钙化。
PLoS One. 2014 Jan 21;9(1):e85922. doi: 10.1371/journal.pone.0085922. eCollection 2014.