Sarfraz Humaira, Zahra Fatima Tuz, Joshi Utsav, O'Connor Tracey
University of Alabama at Birmingham, ONeal Comprehensive Cancer Center NP2512 1720 2 Avenue South, Birmingham, AL, 35294-3300, USA.
Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL, 33612, USA.
Curr Oncol Rep. 2025 Jun 13. doi: 10.1007/s11912-025-01687-x.
Breast cancer survivors experience unique treatment-related side effects that have long-standing and life-altering implications. These remain a challenging aspect both in terms of diagnosis and management for these patients.
This article is a review of the latest key literature in the management of common side effects of treatment in breast cancer survivors namely infertility, vasomotor symptoms, sexual dysfunction, peripheral neuropathy, lymphedema, musculoskeletal symptoms, anthracycline-related cardiotoxicity, secondary malignancies, role of ctDNA, lifestyle modifications, strategies to maintain bone mineral density and addressing fear of cancer recurrence.
Recent research in the field has led to novel advancements for survivors planning a family, pharmacotherapeutic options for hot flashes, overcoming barriers such as adherence to therapy and management of long-term side effects, and a incorporating a multimodal approach to improve sexual health in women, neuropathy, musculoskeletal issues and lymphedema. There have been significant strides in the understanding and management of issues in breast cancer survivors. The increasing awareness and multimodal approach will continue to improve outcomes for survivors.
乳腺癌幸存者会经历独特的与治疗相关的副作用，这些副作用具有长期且改变生活的影响。无论是对这些患者的诊断还是管理，这仍然是一个具有挑战性的方面。
本文回顾了乳腺癌幸存者治疗常见副作用管理方面的最新关键文献，这些副作用包括不孕、血管舒缩症状、性功能障碍、周围神经病变、淋巴水肿、肌肉骨骼症状、蒽环类药物相关心脏毒性、继发性恶性肿瘤、循环肿瘤DNA（ctDNA）的作用、生活方式改变、维持骨密度的策略以及应对癌症复发恐惧。
该领域的最新研究为计划生育的幸存者带来了新进展，为潮热提供了药物治疗选择，克服了诸如坚持治疗和长期副作用管理等障碍，并采用多模式方法改善女性的性健康、神经病变、肌肉骨骼问题和淋巴水肿。在乳腺癌幸存者问题的理解和管理方面已经取得了重大进展。意识的提高和多模式方法将继续改善幸存者的治疗效果。
