Bharucha N E, Raven R H, Schoenberg B S
Arch Neurol. 1985 Nov;42(11):1061-2. doi: 10.1001/archneur.1985.04060100043018.
Current data indicate that mortality for primary malignant nervous system neoplasms (NSNs) provides a fairly accurate index of incidence. Average annual age- and sex-specific death rates among whites for primary malignant NSNs in the 48 contiguous United States from 1940 through 1975 showed a marked cohort effect among the elderly of either sex. For white men aged 60 through 64 years, mortality increased steadily from 5.3 per 100,000 per year for those born in 1880 to 16.1 per 100,000 per year for the 1910 cohort. No definite cohort effect was seen in the young. The increase in mortality could be due to better diagnosis and more complete case ascertainment for deaths due to primary malignant NSNs, but further studies are required to distinguish a real from an artifactual increase in mortality.
目前的数据表明，原发性恶性神经系统肿瘤（NSNs）的死亡率提供了一个相当准确的发病率指标。1940年至1975年期间，美国48个相邻州白人原发性恶性NSNs的平均年度年龄和性别特异性死亡率显示，老年男性和女性中存在明显的队列效应。对于60至64岁的白人男性，死亡率从1880年出生者的每年每10万人5.3例稳步上升至1910年队列的每年每10万人16.1例。在年轻人中未观察到明确的队列效应。死亡率的增加可能是由于对原发性恶性NSNs导致的死亡进行了更好的诊断和更完整的病例确诊，但需要进一步研究以区分死亡率的真实增加和人为增加。
