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红细胞计数作为中国2型糖尿病患者微血管并发症的一个指标。

Red blood cell count as an indicator of microvascular complications in Chinese patients with type 2 diabetes mellitus.

作者信息

Wang Zhan-Sheng, Song Zhan-Chun, Bai Jing-Hui, Li Fei, Wu Tao, Qi Ji, Hu Jian

机构信息

Department of Cardiology, First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.

出版信息

Vasc Health Risk Manag. 2013;9:237-43. doi: 10.2147/VHRM.S43211. Epub 2013 May 14.

DOI:10.2147/VHRM.S43211
PMID:23690689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3656917/
Abstract

BACKGROUND

Rheological disorders of red blood cells (RBC) and decreased RBC deformability have been involved in the development of diabetic microangiopathy. However, few studies have evaluated the association of RBC count with microvascular complications in patients with type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the association of RBC count with microvascular complications in patients with T2DM.

METHODS

This study involved 369 patients with T2DM: 243 with one or more microvascular complications and 126 without microvascular complications. Anticoagulated blood was collected and analyzed in an automated blood cell counter. The presence of risk factors for microvascular complications was determined.

RESULTS

The proportion of patients with microvascular complications increased as the RBC count decreased (P < 0.001). After adjustment for known risk factors for microvascular complications by logistic regression analysis, lower quartiles of RBC count were associated with a higher risk of microvascular complications compared with the reference group composed of the highest quartile (first quartile, odds ratio 4.98, 95% confidence interval 1.54-6.19, P = 0.008; second quartile, odds ratio 3.21, 95% confidence interval 1.17-5.28, P = 0.024).

CONCLUSION

A decreased RBC count is associated with microvascular complications in Chinese patients with T2DM. The RBC count is a potential marker to improve further the ability to identify diabetic patients at high risk of microvascular complications.

摘要

背景

红细胞流变学紊乱及红细胞变形性降低与糖尿病微血管病变的发生有关。然而，很少有研究评估2型糖尿病（T2DM）患者红细胞计数与微血管并发症之间的关联。本研究旨在探讨T2DM患者红细胞计数与微血管并发症之间的关联。

方法

本研究纳入369例T2DM患者，其中243例有1种或多种微血管并发症，126例无微血管并发症。采集抗凝血液并在自动血细胞计数器上进行分析。确定微血管并发症的危险因素。

结果

随着红细胞计数降低，微血管并发症患者的比例增加（P<0.001）。通过逻辑回归分析对微血管并发症的已知危险因素进行校正后，与由最高四分位数组成的参照组相比，红细胞计数较低的四分位数与微血管并发症的较高风险相关（第一四分位数，比值比4.98，95%置信区间1.54-6.19，P=0.008；第二四分位数，比值比3.21，95%置信区间1.17-5.28，P=0.024）。

结论

红细胞计数降低与中国T2DM患者的微血管并发症相关。红细胞计数是一种潜在标志物，可进一步提高识别微血管并发症高危糖尿病患者的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8969/3656917/eefa50fb99d1/vhrm-9-237Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8969/3656917/eefa50fb99d1/vhrm-9-237Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8969/3656917/eefa50fb99d1/vhrm-9-237Fig1.jpg

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