Gordji-Nejad Ali, Matusch Andreas, Kleedörfer Sophie, Patel Harshal Jayeshkumar, Drzezga Alexander, Elmenhorst David, Binkofski Ferdinand, Bauer Andreas
Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, Jülich, Germany.
Division of Clinical Cognitive Sciences, Department of Neurology Uniklinik RWTH Aachen, RWTH Aachen University Hospital, Aachen, Germany.
Front Neurosci. 2025 May 30;19:1515761. doi: 10.3389/fnins.2025.1515761. eCollection 2025.
The human brain exhibits asymmetric hemispheric activity at night; this plays a crucial role in cognitive impairment from sleep deprivation. Although there have been many investigations on this topic, there are no studies on hemispheric differences in the consumption of high-energy phosphates (HEP). We present here a new data analysis of our previously published study in which subjects were measured for changes in high-energy phosphate (HEP), tCr/tNAA, and Glu/TNAA during subacute sleep deprivation (21 h) and cognitive tests. In our new analysis, we investigated differences and asymmetries in the metabolic consumption of both hemispheres. Comprehensive per-individual voxel-wise interhemispheric comparisons at all time points and conditions showed a greater decrease from baseline of ATP in the right than in the left hemisphere. Partial volume correction yielded an apparent higher decline of PCr/Pi in gray versus white matter. We also investigated whether creatine supplementation, which has been shown to prevent cognitive impairment during sleep deprivation, affected this hemispheric asymmetry. In a second session, the subjects took a high single dose of creatine monohydrate suspension (0.35 g/kg) after baseline measurements. Creatine balanced the sleep deprivation-induced asymmetry to a higher degree in the left hemisphere, which was due to an increase in PCr/Pi and decrease in ATP. Our results confirm-via the observed decrease in ATP level-a night-active right hemisphere. Creatine administration balanced this asymmetry.
人类大脑在夜间表现出不对称的半球活动；这在睡眠剥夺导致的认知障碍中起着关键作用。尽管对此主题已有许多研究，但尚无关于高能磷酸盐（HEP）消耗的半球差异的研究。我们在此展示对我们先前发表的研究的新数据分析，该研究中测量了受试者在亚急性睡眠剥夺（21小时）和认知测试期间高能磷酸盐（HEP）、tCr/tNAA和Glu/TNAA的变化。在我们的新分析中，我们研究了两个半球代谢消耗的差异和不对称性。在所有时间点和条件下进行的全面的个体体素水平的半球间比较显示，右侧半球ATP相对于基线的下降幅度大于左侧半球。部分容积校正显示灰质中PCr/Pi的下降明显高于白质。我们还研究了已被证明可预防睡眠剥夺期间认知障碍的肌酸补充剂是否会影响这种半球不对称性。在第二个阶段，受试者在基线测量后服用了高剂量的一水肌酸悬浮液（0.35 g/kg）。肌酸在更大程度上平衡了睡眠剥夺引起的左侧半球不对称性，这是由于PCr/Pi增加和ATP减少所致。我们的结果通过观察到的ATP水平下降证实了右侧半球在夜间活跃。给予肌酸平衡了这种不对称性。
