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宫颈神经内分泌癌肾周转移:1例报告并文献复习

Peri-renal metastasis of cervical neuroendocrine carcinoma: a case report and literature review.

作者信息

Sangnoppatham Nopparuj, Jitjaturunt Natchaya, Wongyongsil Jitpanu, Wisawasukmongchol Winn, Thaweepworadej Panya

机构信息

Division of General Surgery, Department of Surgery, Bangkok Metropolitan Administration (BMA) General Hospital, 514 Luang Road, Pom Prap Subdistrict, Pom Prap Sattru Phai District, Bangkok 10100, Thailand.

Division of Urology, Department of Surgery, Bangkok Metropolitan Administration (BMA) General Hospital, 514 Luang Road, Pom Prap Subdistrict, Pom Prap Sattru Phai District, Bangkok 10100, Thailand.

出版信息

J Surg Case Rep. 2025 Jun 13;2025(6):rjaf412. doi: 10.1093/jscr/rjaf412. eCollection 2025 Jun.

DOI:10.1093/jscr/rjaf412
PMID:40521037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12165706/
Abstract

Neuroendocrine carcinoma of the cervix (NECC) is a rare pathological subtype of cervical cancer and patients with NECC usually develop metastasis at the time of diagnosis. While NECC commonly metastasizes to the liver, lungs, and bones, it rarely spreads to renal or peri-renal region. We report a case of a 59-year-old woman with metastatic NECC with peri-renal metastasis. After an en-bloc resection of the kidney, spleen, and distal pancreas, the pathological results suggested metastatic NECC. Further metastatic workup revealed three additional metastases in the bone, mediastinum, and axillary lymph nodes.

摘要

宫颈神经内分泌癌(NECC)是宫颈癌中一种罕见的病理亚型,NECC患者通常在确诊时就已发生转移。虽然NECC常见转移至肝脏、肺和骨骼,但很少扩散至肾脏或肾周区域。我们报告一例59岁女性转移性NECC伴肾周转移的病例。在对肾脏、脾脏和胰腺远端进行整块切除后,病理结果提示为转移性NECC。进一步的转移灶检查发现骨骼、纵隔和腋窝淋巴结还有另外三处转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719e/12165706/fc1f71d13170/rjaf412f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719e/12165706/7df6c77c3f46/rjaf412f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719e/12165706/fc1f71d13170/rjaf412f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719e/12165706/7df6c77c3f46/rjaf412f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/719e/12165706/fc1f71d13170/rjaf412f2.jpg

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本文引用的文献

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Neuroendocrine neoplasms of head and neck, genitourinary and gynaecological systems, unknown primaries, parathyroid carcinomas and intrathyroid thymic neoplasms: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.头颈部、泌尿生殖系统及妇科系统神经内分泌肿瘤、原发灶不明肿瘤、甲状旁腺癌及甲状腺内胸腺肿瘤:ESMO临床实践指南之诊断、治疗及随访
ESMO Open. 2024 Oct;9(10):103664. doi: 10.1016/j.esmoop.2024.103664. Epub 2024 Oct 1.
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Pathogenesis, diagnosis and treatment of primary renal well-differentiated neuroendocrine tumors: a review of the literature.原发性肾高分化神经内分泌肿瘤的发病机制、诊断与治疗:文献综述
Front Oncol. 2024 Oct 4;14:1298559. doi: 10.3389/fonc.2024.1298559. eCollection 2024.
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Metastatic rectal neuroendocrine tumor to kidney, pancreas, and bone following renal tumor resected with robot-assisted laparoscopic partial nephrectomy.
肾肿瘤经机器人辅助腹腔镜部分肾切除术后发生转移至肾脏、胰腺和骨骼的直肠神经内分泌肿瘤
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Front Endocrinol (Lausanne). 2022 Aug 16;13:924414. doi: 10.3389/fendo.2022.924414. eCollection 2022.
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High prevalence of p16 staining in malignant tumors.恶性肿瘤中 p16 染色的高发生率。
PLoS One. 2022 Jul 21;17(7):e0262877. doi: 10.1371/journal.pone.0262877. eCollection 2022.
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World J Clin Oncol. 2021 Oct 24;12(10):897-911. doi: 10.5306/wjco.v12.i10.897.
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Pancreatic Cancer: A Review.胰腺癌:综述。
JAMA. 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027.
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