神经内分泌型宫颈癌的远处器官转移模式和预后：一项基于人群的回顾性研究。
Distant organ metastasis patterns and prognosis of neuroendocrine cervical carcinoma: a population-based retrospective study.
机构信息
Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jiangxi Key Laboratory of Clinical and Translational Cancer Research, Nanchang, China.
出版信息
Front Endocrinol (Lausanne). 2022 Aug 16;13:924414. doi: 10.3389/fendo.2022.924414. eCollection 2022.
BACKGROUND
Neuroendocrine carcinoma of the cervix (NECC) is a rare pathological form of cervical cancer. The prognosis of NECC with distant organ metastases is unclear. In our study, the patterns and prognosis of distant organ metastasis of NECC were investigated.
METHODS
Data were obtained from the surveillance epidemiology and end results (SEER) database from 2000 to 2018. Cox regression, Kaplan-Meier and log-rank analyses were conducted.
RESULTS
NECC was prone to single and multi-site metastases. The median overall survival (OS) was greatly decreased in patients with distant metastasis ( < 0.0001). Other characteristics such as age ≥60 years, poorer grade, higher T stage, those without surgery, no radiotherapy, and no chemotherapy were predictors of poor prognosis.
CONCLUSIONS
Metastasis is an independent prognostic factor for patients with NECC. Surgery, radiotherapy, and chemotherapy give an overall survival advantage for patients with distant organ metastases.
背景
宫颈神经内分泌癌（NECC）是一种罕见的宫颈癌病理类型。伴有远处器官转移的 NECC 的预后尚不清楚。在本研究中，我们探讨了 NECC 远处器官转移的模式和预后。
方法
数据来自 2000 年至 2018 年的监测、流行病学和最终结果（SEER）数据库。采用 Cox 回归、Kaplan-Meier 和对数秩检验进行分析。
结果
NECC 易发生单发和多发转移。远处转移患者的中位总生存期（OS）明显降低（<0.0001）。其他特征，如年龄≥60 岁、较差的分级、较高的 T 分期、未手术、未放疗和未化疗，是预后不良的预测因素。
结论
转移是 NECC 患者的独立预后因素。手术、放疗和化疗为远处器官转移患者带来总生存优势。
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