Prete P E, Gurakar-Osborne A
Department of Veterans Affairs Medical Center, Long Beach, CA 90822, USA.
Prostaglandins. 1997 Oct;54(4):689-98. doi: 10.1016/s0090-6980(97)00147-0.
Lipids in the synovial fluid of patients with active rheumatoid arthritis are elevated compared to normal synovial fluid and that of other inflammatory arthropathies. Various assumptions about the role of these lipids have been made. This study offers evidence that these lipids may contribute to the synovitis in rheumatoid arthritis through participation in the arachidonic pathway within the joint space. Phospholipase A2 activity, phospholipids, prostaglandin E2, and leukotriene B4 have been correlated in the synovial fluid and plasma of untreated rheumatoid patients and compared with that of patients with osteoarthritis.
与正常滑液及其他炎性关节病的滑液相比，活动期类风湿关节炎患者滑液中的脂质水平升高。关于这些脂质的作用已有多种假设。本研究提供了证据，表明这些脂质可能通过参与关节腔内的花生四烯酸途径而导致类风湿关节炎中的滑膜炎。在未经治疗的类风湿患者的滑液和血浆中，已将磷脂酶A2活性、磷脂、前列腺素E2和白三烯B4进行了关联，并与骨关节炎患者进行了比较。
