膦酰乙酰-L-天冬氨酸：一种天冬氨酸转氨甲酰酶抑制剂，可导致黑腹果蝇幼虫死亡和翅膀发育不全的表型模拟。 - Suppr

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超能文献

Phosphonacetyl-L-aspartate: an aspartate transcarbamylase inhibitor causing larval death and rudimentary wing phenocopies in Drosophila melanogaster.

作者信息

Holaday B J, Fristrom J W

出版信息

Experientia. 1977 Apr 15;33(4):428-30. doi: 10.1007/BF01922192.

DOI:10.1007/BF01922192

PMID:405235

Abstract

摘要

相似文献

Phosphonacetyl-L-aspartate: an aspartate transcarbamylase inhibitor causing larval death and rudimentary wing phenocopies in Drosophila melanogaster.膦酰乙酰-L-天冬氨酸：一种天冬氨酸转氨甲酰酶抑制剂，可导致黑腹果蝇幼虫死亡和翅膀发育不全的表型模拟。

Experientia. 1977 Apr 15;33(4):428-30. doi: 10.1007/BF01922192.

Overproduction of the first three enzymes of pyrimidine nucleotide biosynthesis in Drosophila cells resistant to N-phosphonacetyl-L-aspartate.在对N-膦酰基乙酰-L-天冬氨酸具有抗性的果蝇细胞中嘧啶核苷酸生物合成的前三种酶的过量产生

Exp Cell Res. 1986 Apr;163(2):381-95. doi: 10.1016/0014-4827(86)90069-8.

Kinetic parameters of aspartate transcarbamylase in human normal and tumoral cell lines.人正常及肿瘤细胞系中天冬氨酸转氨甲酰酶的动力学参数

Cancer Res. 1983 May;43(5):2277-82.

N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture.N-（膦酰基乙酰基）-L-天冬氨酸，一种天冬氨酸转氨甲酰酶的有效过渡态类似物抑制剂，可阻断培养的哺乳动物细胞的增殖。

J Biol Chem. 1974 Nov 10;249(21):6945-50.

Enzymatic assay for the antitumor agent-N-(phosphonacetyl)-L-aspartic acid (PALA).抗肿瘤药物N-（膦酰乙酰基）-L-天冬氨酸（PALA）的酶活性测定

Cancer Treat Rep. 1979 Jan;63(1):85-8.

Flux through the de novo pyrimidine pathway in vivo. Effect of N-phosphonacetyl-L-aspartate, a potent inhibitor of aspartate transcarbamylase.体内从头嘧啶途径的通量。天冬氨酸转氨甲酰酶的强效抑制剂N-膦酰乙酰-L-天冬氨酸的作用。

J Biol Chem. 1983 Nov 25;258(22):13564-9.

N-(Phosphonacetyl)-L-aspartate inhibition of the enzyme complex of pyrimidine biosynthesis.N-（膦酰基乙酰基）-L-天冬氨酸对嘧啶生物合成酶复合物的抑制作用

Biochem Pharmacol. 1982 Oct 15;31(20):3313-6. doi: 10.1016/0006-2952(82)90566-4.

Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase.N-（膦酰基乙酰基）-L-天冬氨酸对小鼠肿瘤及正常组织的体内外作用以及敏感性与增殖速率和天冬氨酸转氨甲酰酶水平的关系

Cancer Res. 1978 Feb;38(2):371-8.

Inhibition by N-(phosphonacetyl)-L-aspartate of aspartate transcarbamylase activity and drug-induced cell proliferation in mice.

J Biol Chem. 1974 Nov 10;249(21):6951-5.

The binding of N-(phosphonacetyl)-L-aspartate to aspartate carbamoyltransferase of Escherichia coli.

Biochem Biophys Res Commun. 1986 Apr 29;136(2):822-6. doi: 10.1016/0006-291x(86)90514-0.

本文引用的文献

A specific nutritional requirement for pyrimidines in rudimentary mutants of Drosophila melanogaster.黑腹果蝇原始突变体中嘧啶的特定营养需求。

Hereditas. 1970;66(2):205-14. doi: 10.1111/j.1601-5223.1970.tb02346.x.

Aspartate transcarbamylase. Interaction with the transition state analogue N-(phosphonacetyl)-L-aspartate.天冬氨酸转氨甲酰酶。与过渡态类似物N-（膦酰乙酰基）-L-天冬氨酸的相互作用。

J Biol Chem. 1971 Nov;246(21):6599-605.

Pyrimidine metabolism in microorganisms.微生物中的嘧啶代谢

Bacteriol Rev. 1970 Sep;34(3):278-343. doi: 10.1128/br.34.3.278-343.1970.

J Biol Chem. 1974 Nov 10;249(21):6945-50.

Functional diversity within the rudimentary locus of Drosophila melanogaster.黑腹果蝇原始基因座内的功能多样性。

Mol Gen Genet. 1974;135(2):113-22. doi: 10.1007/BF00264779.

The biochemical genetics of rudimentary mutants of Drosophila melanogaster. I. Aspartate carbamoyltransferase levels in complementing and non-complementing strains.黑腹果蝇发育不全突变体的生化遗传学。I. 互补和非互补菌株中天冬氨酸氨甲酰基转移酶水平

Hereditas. 1973;73(1):11-6.

Sex-linked auxotrophic and putative auxotrophic mutants of Drosophila melanogaster.黑腹果蝇的性连锁营养缺陷型和假定营养缺陷型突变体。

Genetics. 1974 Apr;76(4):755-66. doi: 10.1093/genetics/76.4.755.

6-Azauracil induced phenocopies of rudimentary wing mutants and their suppression by a suppressor mutant of rudimentary in Drosophila melanogaster.6-氮尿嘧啶诱导黑腹果蝇残翅突变体表型模拟及其被残翅抑制突变体抑制的研究

Hereditas. 1973;73(2):239-46. doi: 10.1111/j.1601-5223.1973.tb01085.x.

A complex genetic locus that controls of the first three steps of pyrimidine biosynthesis in Drosophila.一个控制果蝇嘧啶生物合成前三个步骤的复杂基因座。

Nature. 1975 Jun 26;255(5511):738-40. doi: 10.1038/255738a0.

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