Klaver J H, Greve E L, Goslinga H, Geijssen H C, Heuvelmans J H
Br J Ophthalmol. 1985 Oct;69(10):765-70. doi: 10.1136/bjo.69.10.765.
Blood viscosity at 10 shear rates, plasma viscosity, packed cell volume, plasma fibrinogen, serum alpha 2-macroglobulin, and serum proteins were measured in 83 patients with low-tension glaucoma (LTG) and 23 patients with 'high-tension glaucoma' (HTG: at least one IOP reading above 40 mmHg) and compared with those in 50 controls. Blood and plasma viscosity values and packed cell volume were significantly higher in the LTG group than those in controls. The HTG and the LTG groups differed only in plasma viscosity, but smoking and drinking habits in the HTG patients were greatly different from those in LTG patients and controls, thus preventing interpretation of data in the HTG group. Within the LTG group viscosity values were highest in a subgroup designated earlier by us as focal ischaemic LTG, whereas another subgroup, senile sclerotic LTG, did not show significant differences compared with controls. These findings may indicate a factor in the pathogenesis of visual field defects and disc cupping in some patients with LTG.
在83例低眼压性青光眼（LTG）患者和23例“高眼压性青光眼”（HTG：至少一次眼压读数高于40 mmHg）患者中测量了10种剪切速率下的血液粘度、血浆粘度、血细胞比容、血浆纤维蛋白原、血清α2-巨球蛋白和血清蛋白，并与50名对照组患者进行了比较。LTG组的血液和血浆粘度值以及血细胞比容显著高于对照组。HTG组和LTG组仅在血浆粘度方面存在差异，但HTG患者的吸烟和饮酒习惯与LTG患者及对照组有很大不同，因此无法对HTG组的数据进行解读。在LTG组中，粘度值在我们之前指定为局灶性缺血性LTG的亚组中最高，而另一个亚组，即老年性硬化性LTG，与对照组相比没有显著差异。这些发现可能表明在一些LTG患者的视野缺损和视盘凹陷的发病机制中存在一个因素。
