Onji Makoto, Ohta Takanori, Kakizoe Shinji
Department of Rehabilitation, Kitakyushu Municipal Medical Center, Kitakyushu, JPN.
Department of Hematology, Kitakyushu Municipal Medical Center, Kitakyushu, JPN.
Cureus. 2025 May 15;17(5):e84187. doi: 10.7759/cureus.84187. eCollection 2025 May.
Intensive care unit-acquired weakness (ICU-AW) is common in patients with sepsis, multiple organ failure, or prolonged mechanical ventilation; however, reports of ICU-AW during periods of immunodeficiency and cytopenia associated with leukemia treatment are limited. This report describes a case of a patient with leukemia who developed severe ICU-AW and was successfully managed with enhanced rehabilitation that progressively increased in both intensity and frequency. A female patient in her late 50s, diagnosed with acute myeloid leukemia and undergoing postremission therapy, developed aspiration pneumonia and required mechanical ventilation. She exhibited severe ICU-AW after extubation. After enhanced rehabilitation, including standing and walking exercises and strength training based on her clinical indicators, significant improvements in muscle strength and activities of daily living were achieved. She was discharged 72 days after extubation with no severe adverse events during rehabilitation. This report suggests that enhanced rehabilitation may be effective and safe in patients with severe ICU-AW who have immunodeficiency and pancytopenia.
重症监护病房获得性肌无力（ICU-AW）在脓毒症、多器官功能衰竭或长期机械通气的患者中很常见；然而，关于白血病治疗期间免疫缺陷和血细胞减少期发生ICU-AW的报道有限。本报告描述了1例白血病患者发生严重ICU-AW并通过强化康复成功治疗的病例，康复强度和频率均逐步增加。1例50多岁的女性患者，诊断为急性髓系白血病并接受缓解后治疗，发生吸入性肺炎，需要机械通气。拔管后她出现了严重的ICU-AW。经过强化康复，包括根据其临床指标进行站立和行走练习以及力量训练，肌肉力量和日常生活活动能力有了显著改善。拔管72天后出院，康复期间未发生严重不良事件。本报告提示，强化康复对于患有免疫缺陷和全血细胞减少的严重ICU-AW患者可能有效且安全。
