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将床尘微生物群与环境因素及儿童呼吸健康联系起来。

Linking the bed dust microbiome with environmental factors and child respiratory health.

作者信息

Šarac Jelena, Havaš Auguštin Dubravka, Šunić Iva, Michl Kristina, Berg Gabriele, Cernava Tomislav, Marjanović Damir, Jakobsen Rasmus Riemer, Lovrić Mario

机构信息

Center for Applied Bioanthropology, Institute for Anthropological Research, Zagreb, Croatia.

Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia.

出版信息

Ann Hum Biol. 2025 Dec;52(1):2509606. doi: 10.1080/03014460.2025.2509606. Epub 2025 Jun 17.

DOI:10.1080/03014460.2025.2509606
PMID:40525799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12312746/
Abstract

BACKGROUND

Humans spend up to 90% of their time indoors and are exposed to a significant number of microbes in their homes, which can have important implications for their health.

AIM

This study focused on analysing the influence of environmental factors on microbiome diversity and abundance in bed dust and linking the exposure to dust bacteria with asthma.

SUBJECTS AND METHODS

A total of 90 dust samples were collected from homes of asthmatic patients ( = 59) and controls ( = 31) aged 5-18 years. The bacterial fraction of the microbiome was analysed using 16S rRNA gene high-throughput sequencing on the Illumina MiSeq platform and downstream analyses in QIIME2 and R. Microbiome profiles were associated with asthma and relevant environmental and household data.

RESULTS

Higher bacterial β-diversity in the environment was shown to be inversely associated with asthma ( = 0.009). Also, living environment ( = 0.002), housing type ( = 0.004), presence of pets in the household ( = 0.001), and cleaning practices ( = 0.006 for dusting and  = 0.011 for vacuuming) were prominent environmental factors affecting the bed dust microbiome.

CONCLUSION

Our results suggest significant differences in bacterial community composition between individuals with and without asthma and the interaction between indoor microbiome and asthma is mediated by environmental factors in the household.

摘要

背景

人类有高达90%的时间待在室内，会接触到家中大量的微生物，这可能对他们的健康产生重要影响。

目的

本研究着重分析环境因素对床尘中微生物群落多样性和丰度的影响，并将接触灰尘细菌与哮喘联系起来。

对象与方法

从5至18岁哮喘患者（n = 59）和对照者（n = 31）的家中总共收集了90份灰尘样本。使用Illumina MiSeq平台上的16S rRNA基因高通量测序以及QIIME2和R中的下游分析来分析微生物群落的细菌部分。微生物群落谱与哮喘以及相关的环境和家庭数据相关联。

结果

环境中较高的细菌β多样性与哮喘呈负相关（P = 0.009）。此外，生活环境（P = 0.002）、房屋类型（P = 0.004）、家中是否有宠物（P = 0.001）以及清洁方式（掸灰尘的P = 0.006，吸尘的P = 0.011）是影响床尘微生物群落的突出环境因素。

结论

我们的结果表明，有哮喘和无哮喘个体之间细菌群落组成存在显著差异，室内微生物群落与哮喘之间的相互作用是由家庭环境因素介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/9f2666e8c3c0/IAHB_A_2509606_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/93e6b4bacf77/IAHB_A_2509606_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/a0063e9b8f28/IAHB_A_2509606_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/abc9fa6792d9/IAHB_A_2509606_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/ea8396319cea/IAHB_A_2509606_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/ed684612cc07/IAHB_A_2509606_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/a7bc1bee71ed/IAHB_A_2509606_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/d75a803236df/IAHB_A_2509606_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/9e65e49a7b9c/IAHB_A_2509606_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/9f2666e8c3c0/IAHB_A_2509606_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/93e6b4bacf77/IAHB_A_2509606_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/a0063e9b8f28/IAHB_A_2509606_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/abc9fa6792d9/IAHB_A_2509606_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/ea8396319cea/IAHB_A_2509606_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/ed684612cc07/IAHB_A_2509606_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/a7bc1bee71ed/IAHB_A_2509606_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/d75a803236df/IAHB_A_2509606_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/9e65e49a7b9c/IAHB_A_2509606_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/12312746/9f2666e8c3c0/IAHB_A_2509606_F0009_C.jpg

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