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体外修复果蝇细胞中紫外线诱导的嘧啶二聚体

Repair of UV-induced pyrimidine dimers in Drosophila melanogaster cells in vitro.

作者信息

Trosko J E, Wilder K

出版信息

Genetics. 1973 Feb;73(2):297-302. doi: 10.1093/genetics/73.2.297.

DOI:10.1093/genetics/73.2.297
PMID:4633159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1212892/
Abstract

Tissue culture cells of Drosophila melanogaster were given various doses of ultraviolet light. The results indicate that Drosophila cells do have a dark-repair excision mechanism which is not sensitive to caffeine. Pyrimidine dimers were destroyed by photoreactivating illumination in these cells and this destruction probably represents monomerization of the pyrimidine dimers.

摘要

给黑腹果蝇的组织培养细胞施加不同剂量的紫外线。结果表明，果蝇细胞确实有一种对咖啡因不敏感的暗修复切除机制。嘧啶二聚体在这些细胞中通过光复活照射而被破坏，这种破坏可能代表嘧啶二聚体的单体化。

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本文引用的文献

1
The proportionality between mutation rate and ultraviolet dose after photoreactivation in Drosophila.果蝇光复活后突变率与紫外线剂量之间的比例关系。
Genetics. 1962 Mar;47(3):361-6. doi: 10.1093/genetics/47.3.361.
2
Photoraactivation: a radiation repair mechanism absent from mammalian cells.
Biochem Biophys Res Commun. 1966 Aug 23;24(4):569-76. doi: 10.1016/0006-291x(66)90359-7.
3
DNA chain elongation and joining in normal human and xeroderma pigmentosum cells after ultraviolet irradiation.紫外线照射后正常人细胞和着色性干皮病细胞中的DNA链延伸与连接
Biophys J. 1972 Sep;12(9):1183-91. doi: 10.1016/S0006-3495(72)86154-X.
4
Mechanisms of radiation mutagenesis in cellular and subcellular systems.细胞和亚细胞系统中的辐射诱变机制。
Annu Rev Nucl Sci. 1969;19:139-78. doi: 10.1146/annurev.ns.19.120169.001035.
5
Mechanism of caffeine enhancement of mutations induced by sublethal ultraviolet dosages.咖啡因增强亚致死剂量紫外线诱导突变的机制。
J Bacteriol. 1968 Jul;96(1):198-204. doi: 10.1128/jb.96.1.198-204.1968.
6
Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation.紫外线照射后，大肠杆菌切除缺陷菌株中合成的DNA的不连续性。
J Mol Biol. 1968 Jan 28;31(2):291-304. doi: 10.1016/0022-2836(68)90445-2.