体外修复果蝇细胞中紫外线诱导的嘧啶二聚体
Repair of UV-induced pyrimidine dimers in Drosophila melanogaster cells in vitro.
作者信息
Trosko J E, Wilder K
出版信息
Genetics. 1973 Feb;73(2):297-302. doi: 10.1093/genetics/73.2.297.
Abstract
Tissue culture cells of Drosophila melanogaster were given various doses of ultraviolet light. The results indicate that Drosophila cells do have a dark-repair excision mechanism which is not sensitive to caffeine. Pyrimidine dimers were destroyed by photoreactivating illumination in these cells and this destruction probably represents monomerization of the pyrimidine dimers.
摘要
给黑腹果蝇的组织培养细胞施加不同剂量的紫外线。结果表明，果蝇细胞确实有一种对咖啡因不敏感的暗修复切除机制。嘧啶二聚体在这些细胞中通过光复活照射而被破坏，这种破坏可能代表嘧啶二聚体的单体化。
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