Gilbert M E, Cain D P
Brain Res. 1985 Oct;354(2):169-80. doi: 10.1016/0165-3806(85)90168-3.
Convulsions were induced in young rats (1-21 days) with pentylenetetrazol or hyperthermia. As adults, these animals were kindled electrically in the basolateral or cortical amygdala, the hippocampus, or the pyriform cortex. Fewer amygdala stimulations were required to evoke major motor seizures in subjects treated at 1, but not at 10 or 21 days of age. No further facilitation in kindling rate was observed in subjects receiving 3 convulsions on days 1, 3 and 5 or 1, 5 and 9. This facilitation of electrical kindling was limited to the amygdaloid sites. The results could not be attributed to gross brain damage or differential convulsion histories. This age-limited, structure-specific effect suggests that the amygdala may represent a unique seizure-generating system in the brain that is sensitive to neural alteration at particular times during development.
用戊四氮或热惊厥法在幼鼠（1 - 21日龄）中诱发惊厥。成年后，对这些动物的基底外侧或皮质杏仁核、海马体或梨状皮质进行电点燃。在1日龄接受处理的实验对象中，诱发大发作性运动性癫痫所需的杏仁核刺激次数较少，而在10日龄或21日龄接受处理的实验对象中则不然。在第1、3和5天或第1、5和9天接受3次惊厥处理的实验对象中，未观察到点燃率的进一步促进。这种对电点燃的促进作用仅限于杏仁核部位。结果不能归因于严重的脑损伤或不同的惊厥史。这种年龄限制、结构特异性效应表明，杏仁核可能代表大脑中一个独特的癫痫发作产生系统，在发育过程中的特定时期对神经改变敏感。
