Lak Mohammadyasin, Karimi Mehdi, Akhgarjand Camellia, Ghotboddin Mohammadi Shirin, Pam Pedram, Ashtary-Larky Damoon, Pirzad Samira, Amirkhan-Dehkordi Mohammadreza, Shahrbaf Mohammad Amin, Henselmans Menno, Asbaghi Omid
Department of Exercise Physiology, Sport Sciences Research Institute, Tehran, Iran.
Faculty of Medicine, Bogomolets National Medical University (NMU), Kiev, Ukraine.
Nutr Metab (Lond). 2025 Jun 17;22(1):61. doi: 10.1186/s12986-025-00959-4.
Weight management remains a global health concern, with increasing interest in nutritional interventions to support healthy body composition. In recent years, the potential role of supplements like Spirulina has gained considerable attention as a possible intervention. This meta-analysis aims to evaluate the effectiveness of Spirulina supplementation on body composition in adults.
A comprehensive search strategy was conducted across online databases to find relevant RCTs from inception until December 2024. The primary endpoints were changes in anthropometric indices. Meta-analysis and meta-regression were performed using STATA software, and sensitivity, subgroup, and publication bias analyses were also conducted.
The pooled analysis of 17 RCTs indicated that Spirulina supplementation significantly reduced body weight (BW) (WMD: -1.07 kg; p = 0.004), body mass index (BMI) (WMD: -0.40; p = 0.025), body fat percentage (BFP) (WMD: -0.84%; p = 0.002), but had no significant effects on waist circumference (WC) (WMD: -0.46 cm; p = 0.280). Based on Egger's regression test, there is no publication bias for BW (p = 0.097), BMI (p = 0.382), BFP (p = 0.945), and WC (p = 0.488). A significant dose-response effect on BMI and intervention dose (Coefficient: -0.17, P = 0.007) and duration (Coefficient: 0.13, p = 0.042).
Spirulina supplementation effectively reduces BW, BMI, and BFP, with stronger effects at higher doses and longer durations, especially in obese or older individuals. While no significant change in WC was observed overall, subgroup analyses suggest potential benefits for specific populations, emphasizing the importance of personalized supplementation strategies.
体重管理仍是全球关注的健康问题，人们对支持健康身体组成的营养干预措施的兴趣日益浓厚。近年来，螺旋藻等补充剂作为一种可能的干预措施，其潜在作用受到了广泛关注。本荟萃分析旨在评估补充螺旋藻对成年人身体组成的有效性。
在在线数据库中进行全面检索，以查找从开始到2024年12月的相关随机对照试验。主要终点是人体测量指标的变化。使用STATA软件进行荟萃分析和荟萃回归，并进行敏感性、亚组和发表偏倚分析。
对17项随机对照试验的汇总分析表明，补充螺旋藻可显著降低体重（WMD：-1.07 kg；p = 0.004）、体重指数（BMI）（WMD：-0.40；p = 0.025）、体脂百分比（BFP）（WMD：-0.84%；p = 0.002），但对腰围（WC）无显著影响（WMD：-0.46 cm；p = 0.280）。根据Egger回归检验，体重、BMI、BFP和WC均不存在发表偏倚（p分别为0.097、0.382、0.945和0.488）。对BMI与干预剂量（系数：-0.17，P = 0.007）和持续时间（系数：0.13，p = 0.042）存在显著的剂量反应效应。
补充螺旋藻可有效降低体重、BMI和BFP，剂量越高、持续时间越长效果越强，尤其是在肥胖或老年个体中。虽然总体上未观察到WC有显著变化，但亚组分析表明对特定人群有潜在益处，强调了个性化补充策略的重要性。
