Liu Lijuan, Wang Fan, Wang Lei, Jiang Xinglin, Zhang Haibo
Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Shandong Energy Institute, Qingdao 266101, China.
Innovation (Camb). 2025 Mar 7;6(6):100871. doi: 10.1016/j.xinn.2025.100871. eCollection 2025 Jun 2.
Microbial manufacturing offers an alternative approach to producing chemicals and materials in a sustainable and environmentally friendly manner. Despite its significance and widespread attention, various challenges persist in its industrial application. We propose a systematic approach to microbial biotechnology-a comprehensive framework for developing customized technologies tailored to the unique characteristics of the entire process for specific products. It utilizes approaches such as simplifying the process, sequential rearrangement, and coupling steps to systematically and holistically address the bottlenecks of the entire process in microbial manufacturing, aiming to achieve optimal economic and environmental benefits. This method involves the integration of multiple disciplines, including enzymology, synthetic biology, metabolic engineering, fermentation, separation engineering, and artificial intelligence (AI) technology. Here, we present several cases involving various stages of product bioproduction, developed under the concept of systematic microbial biotechnology, to demonstrate its effectiveness and advantages. The development and application of these technological concepts hold significant potential to shape the future of a sustainable circular bioeconomy driven by microbial manufacturing.
微生物制造提供了一种以可持续和环境友好的方式生产化学品和材料的替代方法。尽管其具有重要意义并受到广泛关注，但其工业应用仍存在各种挑战。我们提出了一种微生物生物技术的系统方法——一个全面的框架，用于开发针对特定产品整个过程的独特特征量身定制的技术。它利用简化过程、顺序重排和耦合步骤等方法，系统地、全面地解决微生物制造中整个过程的瓶颈问题，旨在实现最佳的经济和环境效益。该方法涉及多个学科的整合，包括酶学、合成生物学、代谢工程、发酵、分离工程和人工智能（AI）技术。在此，我们展示了几个在系统微生物生物技术概念下开发的涉及产品生物生产各个阶段的案例，以证明其有效性和优势。这些技术概念的发展和应用对于塑造由微生物制造驱动的可持续循环生物经济的未来具有巨大潜力。
