Piguet Camille, Celen Zeynep, Meuleman Ben, Schilliger Zoé, Magnus Smith Mariana, Mendola Erik, Pham Eleonore, Jouabli Sondes, Ivanova Vladimira, Murray Ryan J, Klauser Paul, Merglen Arnaud
General Pediatrics Division, Women, Child and Adolescent Department, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Psychiatric Department, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Depress Anxiety. 2025 Jun 10;2025:2679049. doi: 10.1155/da/2679049. eCollection 2025.
Adolescence is marked by major puberty-induced changes including increased reactivity to stress and a peak incidence of mental disorders. The implementation of early interventions during this developmental period is essential to prevent mental disorders. In this clinical trial, we examined the effects of a mindfulness-based intervention (MBI) on internalizing symptoms, affects, and emotion-regulation strategies in a nonclinical sample of young adolescents. Seventy adolescents (41 girls) from the general population, aged between 13 and 15 years, were enrolled in a randomized controlled trial (RCT) that compared an 8-week MBI designed for adolescents and a waiting list. Levels of stress, anxiety and depressive symptoms, positive and negative affects, as well as emotion regulation strategies were measured before and after the intervention (4.8 weeks ± 4 SD) using self-reported questionnaires. We found no effect of our MBI on all self-reported measures, including stress, anxiety, depression, and positive and negative affects, as well as an emotion regulation strategies. Trait mindfulness was negatively correlated with measures of stress, anxiety, and negative affects. The intervention was very well accepted (only one dropout) with a high degree of satisfaction among participants. Individual responses to the intervention were very heterogeneous. Mindfulness practice in non-help-seeking adolescents was very well received, but did not show any benefit on symptoms, affects, or emotion regulation. This is consistent with the literature suggesting a better response in clinical than in nonclinical samples. Longer-term effects remain to be investigated, as does the possibility of identifying individuals who respond best to this early intervention. ClinicalTrials.gov identifier: NCT04711694.
青春期的标志是青春期引发的重大变化,包括对应激反应性增加以及精神障碍发病率达到峰值。在这个发育阶段实施早期干预对于预防精神障碍至关重要。在这项临床试验中,我们研究了基于正念的干预措施(MBI)对青少年非临床样本中内化症状、情感和情绪调节策略的影响。70名年龄在13至15岁之间、来自普通人群的青少年(41名女孩)参加了一项随机对照试验(RCT),该试验比较了为青少年设计的为期8周的MBI和等待名单。在干预前后(4.8周±4标准差)使用自我报告问卷测量压力、焦虑和抑郁症状水平、积极和消极情绪以及情绪调节策略。我们发现MBI对所有自我报告的测量指标均无影响,包括压力、焦虑、抑郁、积极和消极情绪以及情绪调节策略。特质正念与压力、焦虑和消极情绪的测量指标呈负相关。该干预措施得到了很好的接受(仅有一名退出者),参与者满意度很高。个体对干预的反应非常异质。在未寻求帮助的青少年中,正念练习受到了很好的欢迎,但在症状、情绪或情绪调节方面未显示出任何益处。这与文献表明临床样本比非临床样本反应更好一致。长期影响仍有待研究,识别对这种早期干预反应最佳的个体的可能性也有待研究。ClinicalTrials.gov标识符:NCT04711694。