Lubbers Maarten, Jaspers Nova, Claessen Dennis
Microbial Sciences, Institute of Biology, Leiden University, PO Box 9505, 2300 RA, Leiden, the Netherlands.
Biochem Biophys Rep. 2025 Jun 7;43:102076. doi: 10.1016/j.bbrep.2025.102076. eCollection 2025 Sep.
Bacteria come in a wide variety of shapes, ranging from spherical or rod-shaped unicellular cells to complex multicellular structures. These shapes have evolved to benefit the organism in its natural environment. However, industry often takes such organisms from their natural environment to produce useful molecules that favor mankind. Their natural morphology is often far from optimal for use in an industrial setting. Filamentous bacteria, for instance, have a morphology that presents unique challenges for industrial settings. Therefore, various engineering approaches have been developed to optimize their morphology. This review explores a spectrum of successful engineering strategies, offering insights and providing inspiration for future advancements. It holds the potential to lead the way in optimizing morphology in challenging microorganisms and thus improve their exploitability in biotechnology.
细菌有各种各样的形状，从球形或杆状的单细胞到复杂的多细胞结构。这些形状的进化是为了使生物体在其自然环境中受益。然而，工业常常将这些生物体从其自然环境中取出，以生产有利于人类的有用分子。它们的自然形态在工业环境中往往远非最佳。例如，丝状细菌的形态给工业环境带来了独特的挑战。因此，人们开发了各种工程方法来优化它们的形态。本综述探讨了一系列成功的工程策略，为未来的进展提供见解和灵感。它有潜力在优化具有挑战性的微生物形态方面引领道路，从而提高它们在生物技术中的可利用性。
