Tsumori T, Nakao K, Miyata M, Izukura M, Monden Y, Sakurai M, Kawashima Y, Nakahara K
Cancer. 1985 Dec 15;56(12):2843-8. doi: 10.1002/1097-0142(19851215)56:12<2843::aid-cncr2820561221>3.0.co;2-q.
Eighteen patients (10 women and 8 men), ranging in age from 37 to 80 years, with thyroid carcinoma infiltrating the trachea comprised this series. Eleven had primary and 7 had recurrent cases. Total laryngectomy was performed in 4 patients, and tracheal resection was carried out followed by end-to-end anastomosis in 13 patients. In one patient, reconstruction was done with Naville's artificial trachea after tracheal resection. Eleven patients were alive after 1 year and 8 months to 6 years and 7 months after the operation. This result was significantly better than that of a group of ten patients without resection of the infiltrated trachea (seven patients died within 6 months). Thus, combined resection of the upper airway improved the prognosis of advanced thyroid carcinoma with tracheal infiltration. Histologic examination of surgical specimens demonstrated well-differentiated carcinoma in seven patients, poorly differentiated carcinoma in seven patients, undifferentiated carcinoma in three patients, and squamous cell carcinoma in one patient. The result showed a higher frequency of poorly differentiated carcinoma than in the control group of 70 patients without tracheal infiltration.
本系列研究包括18例年龄在37至80岁之间的甲状腺癌侵犯气管患者（10名女性和8名男性）。其中11例为原发性病例，7例为复发病例。4例患者接受了全喉切除术，13例患者进行了气管切除并端端吻合术。1例患者在气管切除后使用纳维尔人工气管进行了重建。11例患者在术后1年8个月至6年7个月存活。该结果明显优于一组未切除受侵气管的10例患者（7例在6个月内死亡）。因此，联合上呼吸道切除术改善了晚期甲状腺癌侵犯气管患者的预后。手术标本的组织学检查显示，7例患者为高分化癌，7例患者为低分化癌，3例患者为未分化癌，1例患者为鳞状细胞癌。结果显示，与70例无气管侵犯的对照组相比，低分化癌的发生率更高。
